Association of ADIPOQ variants with type 2 diabetes mellitus susceptibility in ethnic Han Chinese from northeast China
Association of ADIPOQ variants with type 2 diabetes mellitus susceptibility in ethnic Han Chinese from northeast China
复制标题
ADIPOQ变异与中国东北汉族2型糖尿病易感性的关系
DOI：
10.1111/jdi.12535
复制
发表时间：
2016-11-01
影响因子：
3.2
通讯作者：
Qiao, Hong
中科院分区：
文献类型：
--
作者：
Yao, Meidong;Wu, Yanhui;Qiao, Hong
Aims/IntroductionTo investigate the association between two single nucleotide polymorphisms (SNPs; rs3774261 and rs822393) in the ADIPOQ gene and type 2 diabetes mellitus in Han Chinese from northeast China.Materials and MethodsThe present study comprised 993 type 2 diabetes mellitus patients and 966 unrelated controls from northeastern China. Two SNPs were sequenced using SNPscan. The distribution of genotype frequencies of the two SNPs in ADIPOQ between cases and controls, and in subgroups stratified based on body mass index, were compared using logistic regression analysis. Linear regression was used to analyze the association between each SNP and clinical indicators.ResultsThe GG genotype of rs3774261 increased the risk of type 2 diabetes mellitus compared with the AA genotype in participants with a body mass index
