Biological principles behind accelerated tooth movement
Biological principles behind accelerated tooth movement
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DOI：
10.1053/j.sodo.2015.06.001
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发表时间：
2015-09-01
影响因子：
4.2
通讯作者：
Alikhani, Mani
中科院分区：
文献类型：
--
作者：
Alansari, Sarah;Sangsuwon, Chinapa;Alikhani, Mani
了解牙齿移动的生物学对于开发增加牙齿移动速率的技术具有重要意义。基于对牙齿移动生物学数据的解释，由此产生的加速技术可以分为两大类：一类刺激上游事件以间接激活下游靶细胞，而另一类绕过上游事件并直接刺激下游靶细胞。在这两种方法中，有一个普遍的共识，即牙齿移动的速度是由骨吸收的速度，这反过来又是由破骨细胞活性控制。因此，要提高牙齿移动的速度，破骨细胞应该是治疗的目标。在这篇文章中，这两种方法将进行审查，并讨论每组的生物学局限性。(C)2015爱思唯尔公司All rights reserved.
Understanding the biology of tooth movement has great importance for developing techniques that increase the rate of tooth movement. Based on interpretations of data on the biology of tooth movement, the resulting accelerating techniques can be divided into two main groups: one group stimulates upstream events to indirectly activate downstream target cells, while the other group bypasses the upstream events and directly stimulates downstream target cells. In both approaches, there is a general consensus that the rate of tooth movement is controlled by the rate of bone resorption, which in turn is controlled by osteoclast activity. Therefore, to increase the rate of tooth movement, osteoclasts should be the target of treatment. In this article, both approaches will be reviewed and the biological limitations of each group will be discussed. (C) 2015 Elsevier Inc. All rights reserved.