Early pulmonary cytokine responses to zinc oxide fume inhalation
Early pulmonary cytokine responses to zinc oxide fume inhalation
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DOI：
10.1006/enrs.1997.3765
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发表时间：
1997-10-01
影响因子：
8.3
通讯作者：
Blanc, PD
中科院分区：
文献类型：
--
作者：
Kuschner, WG;DAlessandro, A;Blanc, PD
氧化锌吸入会引起金属烟雾热，这是一种在焊工中常见的流感样综合征。促炎性肺细胞因子在介导这种职业病中发挥作用。本研究的目的是描述实验性人类吸入纯化氧化锌烟雾后早期肺细胞因子反应的特征。我们定量了15名健康志愿者吸入氧化锌烟雾3小时后支气管肺泡灌洗（BAL）细胞因子浓度，我们比较了相同15名受试者的暴露后细胞因子反应与假暴露后反应。我们还将细胞因子反应与之前在氧化锌烟雾暴露后20小时通过BAL研究的14名“后期随访”受试者的细胞因子反应进行了比较。氧化锌暴露是BAL TNF增加的一个统计学显著的、剂量依赖性的预测因子（平均假手术差异+/- SE = 9.5 +/- 3.6 pg/mL，P = 0.02），IL-6（平均假手术-假手术差异+/- SE = 5.5 +/- 1.8 pg/mL，P = 0.009）和IL-8（平均假手术-假手术差异+/- SE = 64.1 +/- 23.9 pg/mL，P = 0.02）。在调整吸烟状态、锌剂量和BAL巨噬细胞后，3小时随访时的TNF反应显着高于20小时随访时（PO = 0.004）。我们的研究结果为吸入氧化锌烟雾后3小时的肺部炎症反应提供了证据，其特征在于BAL促炎细胞因子浓度呈剂量依赖性增加。这些数据表明，TNF在介导金属烟雾热中起着重要的初始作用。(C)北京：科学出版社.
Zinc oxide inhalation causes metal fume fever, a flu-like syndrome common among welders. Proinflammatory pulmonary cytokines play a role in mediating this occupational illness. The goal of this investigation was to characterize early pulmonary cytokine responses after experimental human exposure to inhaled purified zinc oxide fume. We quantified bronchoalveolar lavage (BAL) cytokine concentrations in 15 healthy volunteers 3 hr after inhalation of zinc oxide fume, We compared postexposure cytokine responses with postsham exposure responses in the same 15 subjects. We also com pared cytokine responses with those of 14 ''late follow-up'' subjects previously studied by BAL 20 hr after zinc oxide fume exposure. Zinc oxide exposure was a statistically significant, dose-dependent predictor of increases in BAL TNF (mean exposure-sham difference +/- SE = 9.5 +/- 3.6 pg/mL, P = 0.02), IL-6 (mean exposure-sham difference +/- SE = 5.5 +/- 1.8 pg/mL, P = 0.009), and IL-8 (mean exposure-sham difference +/- SE = 64.1 +/- 23.9 pg/mL, P = 0.02). The TNF response was significantly greater at 3 hr follow-up compared with 20 hr follow-up, after adjusting for smoking status, zinc dose, and BAL macrophages (PO = 0.004). Our findings provide evidence for a pulmonary inflammatory response 3 hr after inhalation of zinc oxide fume characterized by dose-dependent increases in BAL proinflammatory cytokine concentrations. These data indicate that TNF plays an important initial role in mediating metal fume fever. (C) 1997 Academic Press.