Overlap in Frontotemporal Atrophy Between Normal Aging and Patients With Frontotemporal Dementias
Overlap in Frontotemporal Atrophy Between Normal Aging and Patients With Frontotemporal Dementias
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DOI：
10.1097/wad.0b013e31818026c4
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发表时间：
2008-10-01
影响因子：
2.1
通讯作者：
Black, Sandra
中科院分区：
文献类型：
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作者：
Chow, Tiffany W.;Binns, Malcolm A.;Black, Sandra
正常的衰老会导致额皮质萎缩。额颞叶萎缩作为额颞叶痴呆（FTDs）的诊断标准的复杂程度还没有报道。本病例对照研究比较了半自动脑反射提取描绘的额颞叶体积[n = 30例对照vs. 16例行为变异FTD（bvFTD）vs. 14例原发性进行性失语]。Logistic回归确定了对区分bvFTD和原发性进行性失语症与对照最无帮助的区域。线性回归分析病程与萎缩程度的相关性。对照组在体积上表现出很大的差异。对照组的右额叶体积与bvFTD体积显著重叠。但是...正如预期的那样。左前颞部感兴趣体积在区分失语亚组与对照组方面显示91%的准确性。bvFTD组与对照组之间的区别是内侧中额区左侧萎缩，而非右侧萎缩。在正常老化引起的萎缩范围内，将结构成像作为诊断的支持标准是合理的。而容量测定法确定左侧萎缩可用于确定FTD病例。未来的研究应该确定临床医生是否可以在常规诊断性磁共振成像扫描中做出这些区分。
Normal aging leads to frontocortical atrophy. The degree to which this complicates the use of frontotemporal atrophy as a diagnostic criterion for the frontotemporal dementias (FTDs) has not been reported. The present case-control study compared Frontotemporal volumes delineated with semi-automatic brain rep-ion extraction [n = 30 controls vs. 16 behavioral variant FTD (bvFTD) vs. 14 primary progressive aphasia]. Logistic regression identified those regions least helpful for distinguishing bvFTD and primary progressive aphasia from controls. Linear regression tested the correlation Of duration of illness to atrophy severity. The control group showed high variance in volumes. Controls had right frontal lobe volumes that overlapped considerably with bvFTD volumes. but. as anticipated. the left anterior temporal volumes of interest showed 91% accuracy in distinguishing the aphasic subgroup from controls. Left-sided and not right-sided atrophy in the medial middle frontal region distinguished the bvFTD group from controls. The relegation of structural imaging to a supportive criterion For diagnosis is reasonable in the context of the range of atrophy due to normal aging. While volumetry identified left-sided atrophy as useful for identifying FTD cases. future studies Should determine whether clinicians Could make these distinctions on viewing, routine diagnostic magnetic resonance imaging scans.