ANTICARCINOMA ACTIVITY INVIVO OF RHODAMINE-123, A MITOCHONDRIAL-SPECIFIC DYE
ANTICARCINOMA ACTIVITY INVIVO OF RHODAMINE-123, A MITOCHONDRIAL-SPECIFIC DYE
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DOI：
10.1126/science.6623064
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
CHEN, LB
中科院分区：
文献类型：
--
作者：
BERNAL, SD;LAMPIDIS, TJ;CHEN, LB
癌细胞和正常上皮细胞在线粒体对阳离子化合物罗丹明123的保留方面有所不同。探讨了在肿瘤化疗中利用这一差异的可能性。罗丹明123在小鼠体内表现出抗癌活性，这种活性被2-脱氧葡萄糖增强。
Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.