Effects of Caffeine on Myocardial Blood Flow: A Systematic Review.
Effects of Caffeine on Myocardial Blood Flow: A Systematic Review.
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DOI：
10.3390/nu10081083
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发表时间：
2018-08-13
期刊：
影响因子：
5.9
通讯作者：
Oudkerk M
中科院分区：
文献类型：
--
作者：
van Dijk R;Ties D;Kuijpers D;van der Harst P;Oudkerk M
背景咖啡因是世界上消费最广泛的兴奋剂之一。它是一种公认的腺苷拮抗剂，也是血管扩张剂心肌灌注期间假阴性功能测量的潜在原因。本系统综述的目的是总结咖啡因摄入对疑似冠心病患者心肌灌注功能测量影响的证据。使用预定义的电子检索策略检索Pubmed、Web of Science和Embase。健康受试者或已知或疑似CAD患者。比较-最近的咖啡因摄入量与无咖啡因摄入量。功能性心肌灌注的测量结果。研究设计-观察性。14项研究被认为有资格进行本系统综述。在研究设计中有很大范围的变异性，包括不同的成像方式、血管扩张剂、血清咖啡因浓度和主要结果测量。现有数据表明，在腺苷和潘生丁引起的充血期间，近期咖啡因摄入对心脏灌注测量有显著影响。这些影响可能会通过重新分类为不同的风险类别来影响临床决策。
Background. Caffeine is one of the most widely consumed stimulants worldwide. It is a well-recognized antagonist of adenosine and a potential cause of false-negative functional measurements during vasodilator myocardial perfusion. The aim of this systematic review is to summarize the evidence regarding the effects of caffeine intake on functional measurements of myocardial perfusion in patients with suspected coronary artery disease. Pubmed, Web of Science, and Embase were searched using a predefined electronic search strategy. Participants—healthy subjects or patients with known or suspected CAD. Comparisons—recent caffeine intake versus no caffeine intake. Outcomes—measurements of functional myocardial perfusion. Study design—observational. Fourteen studies were deemed eligible for this systematic review. There was a wide range of variability in study design with varying imaging modalities, vasodilator agents, serum concentrations of caffeine, and primary outcome measurements. The available data indicate a significant influence of recent caffeine intake on cardiac perfusion measurements during adenosine and dipyridamole induced hyperemia. These effects have the potential to affect the clinical decision making by re-classification to different risk-categories.
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DOI：
10.1002/jmri.25032
发表时间：
2016-03
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
--
作者：
Kidambi A;Sourbron S;Maredia N;Motwani M;Brown JM;Nixon J;Everett CC;Plein S;Greenwood JP
通讯作者：
Greenwood JP
影响因子：
7.5
作者：
Takx, Richard A. P.;Blomberg, Bjorn A.;Leiner, Tim
通讯作者：
Leiner, Tim
影响因子：
24
作者：
Hendel, RC;Bateman, TM;Mahmarian, JJ
通讯作者：
Mahmarian, JJ
影响因子：
24
作者：
Reyes, Eliana;Loong, Chee Y.;Underwood, S. Richard
通讯作者：
Underwood, S. Richard
DOI：
10.1111/j.1600-0773.1995.tb00111.x
发表时间：
1995-02-01
期刊：
PHARMACOLOGY & TOXICOLOGY
影响因子：
--
作者：
FREDHOLM, BB
通讯作者：
FREDHOLM, BB