Psyllium improves dyslipidaemia, hyperglycaemia and hypertension, while guar gum reduces body weight more rapidly in patients affected by metabolic syndrome following an AHA Step 2 diet
Psyllium improves dyslipidaemia, hyperglycaemia and hypertension, while guar gum reduces body weight more rapidly in patients affected by metabolic syndrome following an AHA Step 2 diet
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DOI：
10.1007/s12349-009-0056-1
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发表时间：
2010-01-01
影响因子：
1.1
通讯作者：
Gaddi, Antonio V.
中科院分区：
文献类型：
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作者：
Cicero, Arrigo F. G.;Derosa, Giuseppe;Gaddi, Antonio V.
本研究的目的是比较评估车前子壳和瓜尔豆胶补充剂对代谢综合征（MS）组分的长期影响。我们将141名MS患者随机分配至可溶性车前子壳粉或瓜尔豆胶3.5 gt.i.d.组。在主餐前20分钟服用，或在标准饮食中累积6个月。两种纤维都显著改善了体重指数（-7.2% vs. -6.5%），空腹血糖（-27.9% vs. -11.1%）和胰岛素（-20.4% vs. -10.8%），HOMA指数（-39.2% vs. -16.7%），糖化血红蛋白治疗6个月后，（-10.4% vs-10.3%）、低密度脂蛋白胆固醇（-7.9% vs-8.5%）和载脂蛋白B（-10.5% vs-5.6%）。只有欧车前补充剂对血浆甘油三酯浓度（-13.3%）以及收缩压（-3.9%）和舒张压（-2.6%）产生显著改善。与基线相比，标准饮食组未观察到显著差异。根据我们的数据，车前子可以更强烈地适用于必须减少大量心血管危险因素的患者，而瓜尔豆胶可以更迅速地有效加强旨在减轻体重的饮食效果。
The aim of this study was to comparatively evaluate the long-term effects of psyllium husk and guar gum supplementation on metabolic syndrome (MS) components. We randomised 141 MS patients to soluble psyllium husk powder or guar gum 3.5 gt.i.d. to be taken 20 min before the main 2 meals, or to a standard diet for a cumulative period of 6 months. Both fibres significantly improved body mass index (-7.2% vs. -6.5%), fasting plasma glucose (-27.9% vs. -11.1%) and insulin (-20.4% vs. -10.8%), HOMA Index (-39.2% vs. -16.7%), glycated haemoglobin (-10.4% vs. -10.3%), low-density lipoprotein cholesterol (-7.9% vs. -8.5%) and apolipo protein B (-10.5% vs. -5.6%), after 6 months of treatment. Only the psyllium supplementation exerted a significant improvement on plasma triglyceride concentration (-13.3%) and systolic (-3.9%) and diastolic blood pressure (-2.6%). No significant difference was observed regarding the standard diet group in comparison to the baseline. On the basis of our data, psyllium could be more strongly indicated for patients that have to reduce a large number of cardiovascular risk factors, while guar gum could be more rapidly efficacious in strengthening the effect of diets aimed at reducing body weight.