The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species
The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species
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苯乙酸在人类、亚人类灵长类动物和一些非灵长类动物中的结合
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
M. Reidenberg
中科院分区：
文献类型：
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作者：
M. James;R. Smith;R. Williams;M. Reidenberg
用~(14)C标记的苯乙酸对人、14种亚人灵长类动物和11种非灵长类动物进行了尿液代谢物检测。在不同物种中发现了该酸的四种氨基酸结合物，即苯乙酰谷氨酰胺、苯乙酰甘氨酸、苯乙酰牛磺酸和二苯乙酰鸟氨酸，但它们的出现情况因物种而异。在灵长类动物中，谷氨酰胺和甘氨酸结合物的出现似乎与它们的进化状态有关。人类只排出谷氨酰胺结合物，东半球猴子和极少量的甘氨酸结合物，新大陆猴子的谷氨酰胺结合物和大量的甘氨酸结合物和原猴只分泌甘氨酸结合物。非灵长类哺乳动物排泄甘氨酸结合物，不分泌谷氨酰胺结合物。被检查的两种鸟类也不同，因为鸽子排泄甘氨酸结合物，而家鸡主要排泄鸟氨酸结合物和少量甘氨酸结合物。首次报道了苯乙酸与牛磺酸的偶联反应。除吸血蝙蝠和家鸡外，所有被研究的物种中都会出现这种情况，但在被研究的物种中，其数量的出现是随机的。在鸽子、雪貂、森林宝宝、卷尾猴、松鼠猴、蒙纳猴和狒狒中发现了大量的它，但在其他物种中只有少量。
14C-Labelled phenylacetic acid has been administered to man, 14 species of sub-human primates and 11 non-primate species and their urine examined for metabolites. Four amino acid conjugates of this acid have been found in various species, namely, phenacetylglutamine, phenacetylglycine, phenacetyltaurine and diphenacetylornithine, but their occurrence varies with species. In the primates the occurrence of the glutamine and glycine conjugates appears to be correlated with their evolutionary status. Man excretes exclusively the glutamine conjugate, the Old World monkeys the glutamine conjugate and very small amounts of the glycine conjugate, the New World monkeys the glutamine conjugate and significant amounts of the glycine conjugate and the prosimians the glycine conjugate only. The non-primate mammalian species excrete the glycine conjugate and no glutamine conjugate. The two avian species examined also differed, since the pigeon excreted the glycine conjugate, whereas the domestic hen excreted mainly the ornithine conjugate with small amounts of the glycine conjugate. The conjugation of phenylacetic acid with taurine is reported for the first time. It occurs in all the species examined except the vampire bat and domestic hen, but its quantitative occurrence is haphazard amongst the species examined. It was found in significant amounts in the pigeon, ferret, bushbaby, capuchin monkey, squirrel monkey, mona monkey and baboon, but in minor amounts in other species.