Late potentials and their relation to ventricular function in human immunodeficiency virus infection.
Late potentials and their relation to ventricular function in human immunodeficiency virus infection.
复制标题
人类免疫缺陷病毒感染中的晚期电位及其与心室功能的关系。
DOI：
10.1016/0002-9149(91)90196-r
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Ross,AM
中科院分区：
文献类型：
--
作者：
Hsia,J;Colan,SD;Adams,S;Ross,AM
对225例有人类免疫缺陷病毒感染血清学证据的患者进行信号平均心电图检查，作为HIV相关心脏病患者和12例血清阴性对照受试者前瞻性纵向研究的一部分。在4个月间隔的连续访视期间，测定信号平均QRS向量的持续时间、向量幅度的末端40 ms的均方根电压和低振幅（< 40 μV）信号的持续时间。59例患者（26%）在首次访视时这些变量中的一个或多个异常; 9例患者（4%）的QRS持续时间>114 ms，55例患者（24%）的均方根电压< 20 μV，43例患者（19%）的低振幅信号持续时间>39 ms。相比之下，血清阴性对照受试者均无任何异常变量（p < 0.03）。在随访期间（平均10 ± 8个月），26例最初正常检查的患者出现异常变量，24例异常信号平均心电图恢复正常。超声心动图采用心率校正的纤维缩短速度-舒张末期室壁应力关系评价左室收缩力。晚电位与收缩异常无关。临床心律失常是罕见的，并没有出现更频繁的晚电位患者。因此，晚电位在感染人类免疫缺陷病毒的患者中既常见又短暂。
Signal-averaged electrocardiograms were performed in 225 patients with serologic evidence of human immunodeficiency virus infection as part of a prospective longitudinal study of patients with HIV-associated heart disease and 12 seronegative control subjects. The duration of signal-averaged QRS vector, root-mean-square voltage of the terminal 40 ms of the vector magnitude and the duration of the low-amplitude (< 40 μV) signal were determined during serial visits at 4-month intervals. One or more of these variables was abnormal on initial visit in 59 of patients (26%); QRS duration was >114 ms in 9 patients (4%), root-mean-square voltage < 20 μV in 55 patients (24%) and low-amplitude signal duration >39 ms in 43 (19%). In contrast, none of the seronegative control subjects had any abnormal variables (p < 0.03). During follow-up (mean 10 ± 8 months), 26 patients with initially normal studies developed abnormal variables and 24 with abnormal signal-averaged electrocardiograms reverted to normal. Left ventricular contractility was assessed by echocardiography using the rate-corrected velocity of fiber shortening-end-diastolic wall stress relation. Late potentials were not related to contractile abnormalities. Clinical arrhythmias were rare and did not appear more frequent among patients with late potentials. Thus, late potentials were both common and evanescent in patients infected with human immunodeficiency virus.