Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease
Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease
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DOI：
10.1016/j.neulet.2012.02.026
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发表时间：
2012-04-04
影响因子：
2.5
通讯作者：
Tooyama, Ikuo
中科院分区：
文献类型：
--
作者：
Kameshima, Naoko;Nanjou, Toshifumi;Tooyama, Ikuo
β-淀粉样肽（A β）的沉积通常在阿尔茨海默病（AD）患者的鼻腔中报道，尽管这一发现的病理意义尚不清楚。这项研究分别比较了鼻区与脑、血液和脑脊液中的A β浓度。免疫组织化学分析鉴定了Tg 2576小鼠鼻上皮中的A β沉积物。酶联免疫吸附测定结果显示，A β 42在鼻区和大脑中的含量之间存在相关性，但与血液中的含量无关。这些结果表明，高度可及的鼻腔可能是基于A β含量的AD诊断分析的有用部位。(c)2012爱思唯尔爱尔兰有限公司保留所有权利。
The deposition of beta-amyloid peptides (A beta) is commonly reported in the nasal cavity of Alzheimer's disease (AD) patients, although the pathological significance of this finding is unknown. This study compared A beta concentrations in the nasal area with those in the brain, blood, and cerebrospinal fluid, respectively. Immunohistochemical analysis identified A beta deposits in the nasal epithelium of Tg2576 mice. Enzyme-linked immunosorbent assay measurements revealed a correlation between the content of A beta 42 in the nasal area and that in the brain, but not with that in the blood. These results suggest that the highly accessible nasal cavity could be a useful site for diagnostic analysis of AD based on A beta content. (c) 2012 Elsevier Ireland Ltd. All rights reserved.