A high performance 2-hydroxynaphthalene Schiff base fluorescent chemosensor for Al3+ and its applications in imaging of living cells and zebrafish in vivo.
A high performance 2-hydroxynaphthalene Schiff base fluorescent chemosensor for Al3+ and its applications in imaging of living cells and zebrafish in vivo.
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DOI：
10.1016/j.saa.2018.08.063
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发表时间：
2019-01
期刊：
影响因子：
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通讯作者：
H. Tian;Xin Qiao;Zhen-Lei Zhang;Cheng-Zhi Xie;Qingzhong Li;Jing‐Yuan Xu
中科院分区：
文献类型：
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作者：
H. Tian;Xin Qiao;Zhen-Lei Zhang;Cheng-Zhi Xie;Qingzhong Li;Jing‐Yuan Xu
由于Al ~（3+）的积累与多种疾病的发生发展密切相关，因此，研制出高性能的Al ~（3+）荧光化学传感器具有重要意义。本文报道了一种高选择性、高灵敏度的2-羟基萘席夫碱荧光探针H3 L，它能识别铝离子，在甲醇溶液中表现出高选择性的“关-开”模式。该探针对Al 3+的检测限低至10− 7 M，这是通过荧光滴定法测定的。H_3L对Al ~（3+）的高选择性和高灵敏度归因于ESIPT的抑制作用。此外，在共聚焦荧光显微镜下可以观察到细胞内Al 3+离子的分布。此外，我们还将H_3L用于活体斑马鱼幼体中Al ~（3+）离子的检测。
Developing high performance fluorescent chemo-sensors forin vitroandin vivoAl3+detection is highly desirable, because Al3+accumulation has been involved to various diseases. Herein, we report a highly selective and sensitive Schiff base fluorescent probe,H3L, based on 2-hydroxynaphthalene, which can recognize aluminum ions and exhibit an “off-on” mode with high selectivity in methanol solutions. The detection limit of the probe for Al3+is as low as 10−7M which was determined by fluorescent titration. The high selectivity and high sensitivity ofH3Lfor Al3+are attributed to the inhibition of ESIPT. Additionally, the distribution of intracellular Al3+ions could be observed under confocal fluorescence microscopy. Moreover, we also appliedH3Lforin vivodetection of Al3+ions in living zebrafish larvae.