Bioactive Wollastonite-Diopside Foams from Preceramic Polymers and Reactive Oxide Fillers
Bioactive Wollastonite-Diopside Foams from Preceramic Polymers and Reactive Oxide Fillers
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DOI：
10.3390/ma8052480
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发表时间：
2015-05-08
期刊：
影响因子：
3.4
通讯作者：
Bernardo E
中科院分区：
文献类型：
--
作者：
Fiocco L;Elsayed H;Ferroni L;Gardin C;Zavan B;Bernardo E
硅灰石（CaSiO 3）和透辉石（CaMgSi 2 O 6）硅酸盐陶瓷作为高生物活性材料，适合于骨组织工程应用，已被广泛研究。在本文中，高度多孔玻璃陶瓷泡沫，与硅灰石和透辉石作为晶相，从硅树脂填充CaO和MgO前体，在微米级颗粒的形式的热处理开发。发泡是由于在低温下，在陶瓷转化之前的聚合物基质中的水释放，主要由用作二次填料的水合磷酸钠操作。该添加剂被证明是“多功能的”，因为它另外通过在烧制时形成液相而有利于相发展，进而促进离子相互扩散。液相也促进了掺入粉末的玻璃结晶本身在硅灰石和透辉石，在结构完整性和抗压强度显着改善。通过细胞培养试验对聚合物衍生的硅灰石-透辉石泡沫进行生物学表征，以评估样品的生物活性。MTT法和LDH活性试验显示细胞活力呈阳性。
Wollastonite (CaSiO3) and diopside (CaMgSi2O6) silicate ceramics have been widely investigated as highly bioactive materials, suitable for bone tissue engineering applications. In the present paper, highly porous glass-ceramic foams, with both wollastonite and diopside as crystal phases, were developed from the thermal treatment of silicone polymers filled with CaO and MgO precursors, in the form of micro-sized particles. The foaming was due to water release, at low temperature, in the polymeric matrix before ceramic conversion, mainly operated by hydrated sodium phosphate, used as a secondary filler. This additive proved to be “multifunctional”, since it additionally favored the phase development, by the formation of a liquid phase upon firing, in turn promoting the ionic interdiffusion. The liquid phase was promoted also by the incorporation of powders of a glass crystallizing itself in wollastonite and diopside, with significant improvements in both structural integrity and crushing strength. The biological characterization of polymer-derived wollastonite-diopside foams, to assess the bioactivity of the samples, was performed by means of a cell culture test. The MTT assay and LDH activity tests gave positive results in terms of cell viability.