Longitudinal changes in brain morphology from 4 weeks to 12 months after mild traumatic brain injury: Associations with cognitive functions and clinical variables
Longitudinal changes in brain morphology from 4 weeks to 12 months after mild traumatic brain injury: Associations with cognitive functions and clinical variables
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DOI：
10.1080/02699052.2017.1283537
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发表时间：
2017-01-01
期刊：
影响因子：
1.9
通讯作者：
Andelic, N.
中科院分区：
文献类型：
--
作者：
Hellstrom, T.;Westlye, L. T.;Andelic, N.
目的：研究轻度创伤性脑损伤（MTBI）患者皮质和皮质下体积的纵向变化，并评估这些变化是否与自我报告的脑震荡后症状、整体功能结局和神经心理功能相关。方法：这是一个前景，复杂性心绞痛患者的纵向队列研究（即在损伤CT当天存在颅内异常）和无并发症的MTBI（即无颅内异常）。在大约4周和12个月时进行磁共振成像（MRI）。我们使用了3 T MRI系统，皮质重建和FreeSurfer软件的体积分割。我们纳入了33例无并发症和29例复杂的MTBI，年龄16-65 years.Results：MTBI后12个月，两组患者组的左侧延髓区和右侧尾状核均检测到组内显著的体积减少，但组间无显著差异。体积变量和脑震荡后症状或全球functioningwere found. The left temporal thickness was significantly associated with executive functioning.Conclusion：复杂和简单的MTBI后发生结构性皮层下改变，但这些发现与症状负担或功能结局无关。尽管如此，左颞叶萎缩的患者执行功能更差。
Objective: To investigate longitudinal changes in cortical and subcortical volumes in patients with mild traumatic brain injury (MTBI) and to evaluate whether such changes were associated with self-reported post-concussive symptoms, global functional outcomes and neuropsychological functioning.Methods: This was a prospecitve, longitudinal cohort study of patients with complicated (i.e presence of intracranial abnormalities on the day of injury CT) and uncomplicated MTBI (i.e, absence of intracranial abnormalities). Magnetic resonance imaging (MRI) was performed at approximately 4 weeks and 12 months. We utilized a 3T MRI system, cortical reconstruction and volumetric segmentation by FreeSurfer software. We included 33 patients with uncomplicated and 29 with complicated MTBI, who were aged 16-65 years.Results: 12 months after MTBI, significant within-group volume reductions were detected in the left accumbens area and right caudate nucleus for both patients groups, but no significant differences between the groups were revealed. No associations between volumetric variables and post-concussive symptoms or global functioning were found. The left temporal thickness was significantly associated with executive functioning.Conclusion: Structural subcortical alterations occur after complicated and uncomplicated MTBIs but these findings were not associated with symptoms burden or functional outcomes. Nonetheless, worse executive functioning was found in patients with shrinkage of the left temporal lobe.