Oral lichen planus: An update on pathogenesis and treatment.
Oral lichen planus: An update on pathogenesis and treatment.
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口服地衣披针形：发病机理和治疗的最新消息。
DOI：
10.4103/0973-029x.84474
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Ranganathan K
中科院分区：
文献类型：
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作者：
Lavanya N;Jayanthi P;Rao UK;Ranganathan K
口腔扁平苔藓（OLP）是一种影响口腔粘膜的慢性炎症性疾病。它是一种T细胞介导的自身免疫性疾病，其中细胞毒性CD8+ T细胞触发口腔上皮基底细胞的凋亡。已经提出了几种抗原特异性和非特异性炎症机制来解释CD8+ T细胞在上皮下的积聚和归巢以及随后的角质形成细胞凋亡。从局部皮质类固醇到激光消融病变，有多种治疗方式可供选择。在这篇综述中，我们讨论了OLP的发病机制和目前的治疗方式的各种概念。
Oral lichen planus (OLP) is a chronic inflammatory disease that affects the mucus membrane of the oral cavity. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+ T cells trigger apoptosis of the basal cells of the oral epithelium. Several antigen-specific and nonspecific inflammatory mechanisms have been put forward to explain the accumulation and homing of CD8+ T cells subepithelially and the subsequent keratinocyte apoptosis. A wide spectrum of treatment modalities is available, from topical corticosteroids to laser ablation of the lesion. In this review, we discuss the various concepts in the pathogenesis and current treatment modalities of OLP.