Type I interferon during viral infections: multiple triggers for a multifunctional mediator.
Type I interferon during viral infections: multiple triggers for a multifunctional mediator.
复制标题
病毒感染期间的 I 型干扰素：多功能介质的多种触发因素。
DOI：
10.1007/978-3-540-71329-6_16
复制
发表时间：
2007
影响因子：
--
通讯作者：
Oldstone,MBA
中科院分区：
文献类型：
--
作者：
Zuniga,EI;Hahm,B;Oldstone,MBA
Type I interferons (IFN-I) orchestrate numerous biological and cellular processes and are essential elements during host antiviral defense. After recognition of highly conserved virus signatures, a complex network of signaling events is rapidly initiated and leads to IFN-I synthesis. These cytokines directly induce a strong antiviral state and exert several immune-regulatory actions aimed at preventing virus spread. On the other hand, viruses evolved to evade or subvert the IFN-I system for their own benefit. In the present article, we review selective aspects of IFN-I induction and functions during several viral infections and discuss the beneficial and detrimental roles of IFN-I illustrated during lymphocytic choriomeningitis virus (LCMV) infection in its natural host, the mouse.
