Nonlinear phase-phase cross-frequency coupling mediates communication between distant sites in human neocortex.
Nonlinear phase-phase cross-frequency coupling mediates communication between distant sites in human neocortex.
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DOI：
10.1523/jneurosci.3688-08.2009
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发表时间：
2009-01-14
期刊：
影响因子：
--
通讯作者：
Ojemann JG
中科院分区：
文献类型：
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作者：
Darvas F;Miller KJ;Rao RP;Ojemann JG
人类的认知被认为是由新皮质中遥远地点之间的大规模相互作用所调节的。不同皮质区域之间的同步化被认为是皮质-皮质相互作用的一种可能机制。在这里，我们报告了在运动任务中，人类大脑皮层中远距离感觉运动部位之间的稳健的、定向的跨频率同步。在四名受试者中，皮质表面的皮层脑电记录显示，在运动前皮质腹侧区域有一个低频节律(10-13赫兹)，与较高的频率(77-82赫兹)结合在一起，在远处运动部位的这两个频率的总和上产生第三个节律。这种交叉频率耦合暗示了这些皮质部位之间的非线性相互作用。这些发现表明，特定于任务的相-相耦合可以支持人类新大脑皮层遥远区域之间的通信。
Human cognition is thought to be mediated by large-scale interactions between distant sites in the neocortex. Synchronization between different cortical areas has been suggested as one possible mechanism for cortico-cortical interaction. Here we report robust, directional cross-frequency synchronization between distant sensorimotor sites in human neocortex during a movement task. In four subjects, electrocorticographic recordings from the cortical surface revealed a low frequency rhythm (10–13Hz) that combined with a higher frequency (77–82Hz) in a ventral region of the pre-motor cortex to produce a 3rd rhythm at the sum of these two frequencies in a distant motor site. Such cross-frequency coupling implies a nonlinear interaction between these cortical sites. These findings demonstrate that task-specific, phase-phase coupling can support communication between distant areas of the human neocortex.