Variations in strength of vertebrae with age and their relation to osteoporosis
Variations in strength of vertebrae with age and their relation to osteoporosis
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DOI：
10.1007/bf02008077
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发表时间：
1967-01-01
期刊：
影响因子：
--
通讯作者：
BECK, J. S.
中科院分区：
文献类型：
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作者：
BELL, G. H.;DUNBAR, OLIVE;BECK, J. S.
第四腰椎和第五腰椎是在26至86岁的人体尸检中获得的。同时取髂骨标本进行骨小梁密度(髂骨评分)的组织学评价。在去除椎弓根和棘突后，在试验机中对椎体进行机械故障压缩。获得了以下值：断裂应力(破坏时的单位面积载荷)、破坏时的应变(变形百分比)和相对灰分含量(灰分/单位体积)。失败时的应变与椎骨的大小和强度无关。相对灰分与髂骨评分密切相关。相对灰分含量和。破碎力均随龄期的增长而下降，但二者之间的关系不是线性的，因为破碎力下降的速度比灰分下降的速度快。欧拉柱屈曲应力的欧拉公式很容易解释在骨质疏松中，垂直骨小梁直径的减小和横向纽带的丧失如何导致强度的损失成比例地大于骨组织的损失。这些结果没有理由认为在骨质疏松症中，骨组织的质量会发生变化。|抽象作者：作者
Fourth and fifth lumbar vertebrae were obtained at post mortem examinations of human subjects in the range 26 to 86 yr. and at the same time specimens were taken from the iliac crests for histological assessment of trabecular density (iliac crest score). After removal of pedicles and spinous processes the vertebrae were compressed in a testing machine to mechanical failure. The following values were obtained; breaking stress (load per unit area at failure), strain (percentage deformation) at failure and relative ash content (ash/unit volume). Strain at failure was independent of the size and strength of the vertebrae. The relative ash content and the iliac crest score were closely correlated. The relative ash content and the . breaking stress both declined with increasing age, but the relation between them was not linear since the breaking stress fell more quickly than the ash content. Euler's equation for the buckling stress of a loaded column readily explains how in osteoporosis the reduction of the diameter of the vertical trabeculae and the loss of transverse ties cause loss of strength proportionately greater than the loss of osseous tissue. The results give no reason to suppose that in osteoporosis the quality of the osseous tissue is changed. || ABSTRACT AUTHORS: Authors