Brain activity during stimulation of the trigeminal nerve with noxious heat
Brain activity during stimulation of the trigeminal nerve with noxious heat
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DOI：
10.1016/j.tripleo.2005.12.018
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发表时间：
2006-12-01
期刊：
影响因子：
--
通讯作者：
Andersen, Anders H.
中科院分区：
文献类型：
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作者：
de Leeuw, Reny;Davis, C. Ervin;Andersen, Anders H.
Objective.本研究的目的是观察疼痛性热刺激三叉神经时大脑激活的区域。9名健康无痛女性（平均年龄26.2 +/- 6.9岁）参加了这项研究，她们的月经周期自然、规律。全脑功能磁共振成像（fMRI）数据采集每个参与者在月经开始后第2天或第3天使用回波平面成像在1.5T与近各向同性的空间分辨率和时间分辨率为4 s。在头部线圈内使用Peltier热电极的全脑fMRI产生了一种可行的成像协议，几乎没有热电极的干扰。左侧三叉神经系统的疼痛性热刺激激活了丘脑、扣带回、丘脑、顶下叶/中央后回、右侧额中回和额下回、楔叶、楔前叶和中央前回内的离散脑区。三叉神经的疼痛刺激导致通常已知用于疼痛外周刺激的疼痛处理的类似脑区域的激活。
Objective. The aim of this study was to observe areas of brain activation with painful hot stimulation to the trigeminal nerve.Study design. Nine healthy pain-free women (mean age 26.2 +/- 6.9 yrs) with a natural, regular menstrual cycle participated in the study. Whole-brain functional magnetic resonance imaging (fMRI) data were acquired for each participant on day 2 or 3 after the onset of menses using echo-planar imaging at 1.5T with near-isotropic spatial resolution and a temporal resolution of 4 s.Results. Whole-brain fMRI with a Peltier thermode inside the head coil yielded a feasible imaging protocol with little disturbance from the thermode. Painful thermal stimulation of the left trigeminal system activated discrete brain regions within the insula, cingulate gyrus, thalamus, inferior parietal lobe/postcentral gyrus, right middle and inferior frontal gyri, cuneus, precuneus, and precentral gyrus.Conclusion. Painful stimulation of the trigeminal nerve resulted in activation of similar brain areas generally known for pain processing of painful peripheral stimulation.