Modality-independent coding of spatial layout in the human brain.
Modality-independent coding of spatial layout in the human brain.
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DOI：
10.1016/j.cub.2011.04.038
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发表时间：
2011-06-07
期刊：
影响因子：
9.2
通讯作者：
Giudice, Nicholas A.
中科院分区：
文献类型：
--
作者：
Wolbers, Thomas;Klatzky, Roberta L.;Loomis, Jack M.;Wutte, Magdalena G.;Giudice, Nicholas A.
在许多非人类物种中，导航信息（如位置和方向）的神经计算并不依赖于特定的感觉方式。相反，空间信号是从多个输入源集成的，可能导致空间的抽象表示。相比之下，人类抽象空间表征的潜力尚不清楚，因为大多数关于人类导航的神经科学实验都只关注视觉线索。在这里，我们测试的模态独立性假设与两个功能磁共振成像实验，其特征在于涉及处理空间布局的区域中的计算。根据这一假设，这些区域应该被招募用于3-D几何配置的空间计算，独立于特定的感觉方式。为了支持这一观点，有视力的参与者表现出强烈的激活海马旁位置区（PPA）和压后皮层（RSC）的视觉和触觉探索的信息匹配的场景，但不是对象。功能连接分析表明，这些影响与视觉编码无关，这进一步得到了盲人参与者对触觉场景的类似偏好的支持。综上所述，这些研究结果建立了PPA/RSC网络在模态独立的空间计算中的关键作用，并为人类大脑中的高级抽象空间信息处理理论提供了重要证据。
In many non-human species, neural computations of navigational information such as position and orientation are not tied to a specific sensory modality. Rather, spatial signals are integrated from multiple input sources, likely leading to abstract representations of space. In contrast, the potential for abstract spatial representations in humans is not known, as most neuroscientific experiments on human navigation have focused exclusively on visual cues. Here, we tested the modality independence hypothesis with two fMRI experiments that characterized computations in regions implicated in processing spatial layout. According to the hypothesis, such regions should be recruited for spatial computation of 3-D geometric configuration, independent of a specific sensory modality. In support of this view, sighted participants showed strong activation of the parahippocampal place area (PPA) and the retrosplenial cortex (RSC) for visual and haptic exploration of information-matched scenes but not objects. Functional connectivity analyses suggested that these effects were not related to visual recoding, which was further supported by a similar preference for haptic scenes found with blind participants. Taken together, these findings establish the PPA/RSC network as critical in modality-independent spatial computations and provide important evidence for a theory of high-level abstract spatial information processing in the human brain.
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