Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria
Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria
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DOI：
10.1016/s0140-6736(01)06040-8
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发表时间：
2001-09-15
期刊：
影响因子：
168.9
通讯作者：
Plowe, CV
中科院分区：
文献类型：
--
作者：
Djimdé, A;Doumbo, OK;Plowe, CV
抗药性恶性疟疾在非洲正在增加，因此需要大规模绘制抗药性地图的方法。氯喹耐药的分子标记pfcrt T76可用于监测临床氯喹耐药。在哨点测量pfcrt T76的患病率和临床氯喹耐药和治疗失败的患病率，并用于计算年龄调整的基因型耐药指数（GRI）和基因型失败指数（GFI）。我们发现稳定的GRI和GFI在不同的网站在邮件，西非。该模型允许使用分子工具在快速和简单的横断面调查中绘制氯喹抗性图。
Drug-resistant falciparum malaria is increasing in Africa and so methods to map resistance on a broad scale are needed. A molecular marker for chloroquine resistance, pfcrt T76, can be used for surveillance of clinical chloroquine resistance. The prevalence of pfcrt T76 and the prevalence of clinical chloroquine resistance and therapeutic failure were measured at sentinel sites and used to calculate age-adjusted genotype-resistance Indices (GRIs) and genotype-failure Indices (GFIs). We found stable GRIs and GFIs at different sites In Mail, West Africa. This model permits mapping of chloroquine resistance using molecular tools in rapid and simple cross-sectional surveys.