Decline in FEV1 related to smoking status in individuals with severe alpha1-antitrypsin deficiency (PiZZ).
Decline in FEV1 related to smoking status in individuals with severe alpha1-antitrypsin deficiency (PiZZ).
复制标题
严重 α1-抗胰蛋白酶缺乏症 (PiZZ) 患者的 FEV1 下降与吸烟状况相关。
DOI：
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发表时间：
1999
影响因子：
24.3
通讯作者：
S. Eriksson
中科院分区：
文献类型：
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作者：
E. Piitulainen;S. Eriksson
严重的 α1-抗胰蛋白酶 (AAT) 缺乏容易发生肺气肿。据报道，PiZZ 个体的肺功能下降速度存在很大差异。对瑞典国家 AAT 缺乏登记册中包含的 608 名成年 PiZZ 个体进行了分析，分析了每秒用力呼气量 (FEV1；delta FEV1) 的年度下降与吸烟状况的关系。在 1 年或更长的随访时间内（中位 5.5 年，范围 1-31）进行至少两次肺量测定后，对 211 名从不吸烟者、351 名戒烟者和 46 名当前吸烟者的 Delta FEV1 进行了分析。从不吸烟者的调整后平均 Delta FEV1 为 47 mL x yr(-1)（95% 置信区间 (CI) 41-53 mL x yr(-1)），戒烟者为 41 mL x yr(-1) (95% CI 36-48 mL x yr(-1))，戒烟者为 70 mL x yr(-1) (95% CI 58-82 mL x yr(-1)) 在当前吸烟者中。在当前吸烟者和戒烟者中发现卷烟消费量与 Delta FEV1 之间存在剂量反应关系。在从不吸烟的人中，50 岁后发现 Delta FEV1 比以前更高。 Delta FEV1 未发现性别差异。总之，在 PiZZ 个体中，从不吸烟者和戒烟者一秒钟用力呼气量的变化基本相同。吸烟与一秒钟用力呼气量变化的剂量依赖性增加有关。
Severe alpha1-antitrypsin (AAT) deficiency predisposes to emphysema development. Highly variable rates of decline in lung function are reported in PiZZ individuals. The annual decline in forced expiratory volume in one second (FEV1; delta FEV1) was analysed in relation to smoking status in a cohort of 608 adult PiZZ individuals included in the Swedish national AAT deficiency register. Delta FEV1 was analysed in 211 never-smokers, in 351 exsmokers, and in 46 current smokers after performing at least two spirometries during a follow-up time of 1 yr or longer (median 5.5 yrs, range 1-31). The adjusted mean delta FEV1 in never-smokers was 47 mL x yr(-1) (95% confidence interval (CI) 41-53 mL x yr(-1)), 41 mL x yr(-1) (95% CI 36-48 mL x yr(-1)) in exsmokers, and 70 mL x yr(-1) (95% CI 58-82 mL x yr(-1)) in current smokers. A dose-response relationship was found between cigarette consumption and delta FEV1 in current smokers and exsmokers. In never-smokers, a greater delta FEV1 was found after 50 yrs of age than before. No sex differences were found in delta FEV1. In conclusion, among PiZZ individuals, the change in forced expiratory volume in one second is essentially the same in never-smokers and exsmokers. Smoking is associated with a dose-dependent increase in the change in forced expiratory volume in one second.