Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody.
Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody.
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发表时间：
1991
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通讯作者：
F. Taylor;A. Chang;W. Ruf;J. Morrissey;L. Hinshaw;R. Catlett;K. Blick;T. Edgington
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文献类型：
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作者：
F. Taylor;A. Chang;W. Ruf;J. Morrissey;L. Hinshaw;R. Catlett;K. Blick;T. Edgington
革兰氏阴性菌血症是一个主要的健康问题，导致住院期间获得的致死性败血性休克病例的一半。细菌内毒素和炎性细胞因子肿瘤坏死因子和白介素1是感染性休克的重要介质。在这些介质的作用中，凝血障碍可能是由诱导巨噬细胞和内皮细胞表达组织因子(TF)所触发的。我们现在报告，500微克/公斤的免疫球蛋白G(Ig G)或抗转铁蛋白的单抗Fab片段作为预处理给狒狒注射，可以减轻凝血障碍，并对LD100大肠杆菌具有保护作用。这项研究为TF在感染性休克中的重要效应作用提供了直接证据。
Gram-negative bacteremia poses a major health problem, causing one-half of cases of lethal septic shock acquired during hospitalization. Bacterial lipopolysaccharide (LPS) and the inflammatory cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), have been shown to be essential mediators of septic shock. Among the effects of these mediators is a coagulopathy that may be triggered by induced expression of tissue factor (TF) on macrophages and endothelial cells. We now report that 500 micrograms/kg of either immunoglobulin G (IgG) or Fab fragments of a monoclonal antibody against TF administered to baboons as a pretreatment attenuates the coagulopathy and protects against LD100 Escherichia coli. This study provides direct evidence of an essential effector role for TF in septic shock.