SEASON OF BIRTH - SCHIZOPHRENIA AND BIPOLAR DISORDER
SEASON OF BIRTH - SCHIZOPHRENIA AND BIPOLAR DISORDER
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DOI：
10.1093/schbul/12.2.173
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发表时间：
1986-01-01
影响因子：
6.6
通讯作者：
STEWART, W
中科院分区：
文献类型：
--
作者：
BOYD, JH;PULVER, AE;STEWART, W
研究调查精神分裂症的风险和出生季节之间的关联进行审查，并明确建立关联。这种关联不能解释的基础上的年龄发病率或年龄患病率文物。其他研究表明，双相情感障碍与出生季节之间可能存在联系。解释出生季节现象的主要理论是，季节性因素（如病毒感染，营养不良，维生素缺乏症，产前或产科并发症，或环境温度）可能会损害婴儿的大脑，从而使儿童日后易患精神病。有证据表明，季节性效应与精神分裂症患者的一个亚组有关，这些患者具有精神病的早期发作，比其他精神分裂症患者的遗传负荷更少，预后更好。需要进行病例对照研究，比较冬季出生和非冬季出生的精神分裂症患者。
Studies investigating the association between the risk of schizophrenia and season of birth are reviewed and the association clearly established. This association cannot be explained on the basis of age-incidence or age-prevalence artifacts. Other studies suggest there may be an association between bipolar disorder and season of birth. The leading theory in explaining the season of birth phenomenon is that a seasonal factor (such as viral infection, malnutrition, vitamin deficiency, prenatal or obstetrical complications, or ambient temperature) can damage an infant's brain and thereby predispose the child to later development of psychosis. Evidence suggests that the seasonal effect is associated with a subgroup of schizophrenics who have early onset of psychosis, less genetic loading than other schizophrenics, and better prognosis. Case–control studies are needed comparing winter-born to nonwinter-born schizophrenics.