Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages.
Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages.
复制标题
不同年龄雌性食蟹猴血清骨转换标志物分析
DOI：
10.3389/fendo.2022.984523
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究的目的是检测不同年龄食蟹猴的骨转换标志物雌二醇、甲状旁腺激素和25羟基维生素D，以提高我们对食蟹猴整个生命周期中骨转换标志物变化的认识，并为建立非人灵长类骨质疏松症模型提供依据。采用双能x线骨密度仪测定了不同年龄食蟹猴的全身骨密度和总骨矿物质含量。采用酶免疫法测定各年龄组血清骨转换标志物水平，采用Spearman秩相关分析评价骨转换标志物与年龄的关系，探讨雌性食蟹猴骨转换标志物与年龄的关系。雌性食蟹猴的全身骨密度在10岁时达到峰值，随后形成一个平稳期，并一直维持到老年。I型胶原的氨基端前肽、骨碱性磷酸酶、骨钙素和c端端端肽在1 ~ 3岁时达到峰值，随着年龄的增长逐渐下降，到10岁时趋于平稳。雌二醇、甲状旁腺激素、25羟维生素D、促卵泡激素、黄体生成素在各年龄组间无显著差异。本文提供了雌性食蟹猴在整个生命周期中骨转换标志物的趋势数据，这与人类的变化相似。
The purpose of this study was to examine bone turnover markers, estradiol, parathyroid hormone, and 25 hydroxyvitamin D, in cynomolgus monkeys at different ages to improve our understanding of the changes in bone turnover markers throughout the life cycle of cynomolgus monkeys and to provide a basis for the establishment of a non-human primate model of osteoporosis. Total Body Bone Mineral Density and Total Body Bone Mineral Content were measured using Dual-Energy X-Ray Absorptiometry in cynomolgus monkeys at different ages. Serum bone turnover marker' levels were measured using enzyme immunoassays at each age group, and the relationship between bone turnover markers and age was assessed by Spearman rank correlation analysis to investigate the relationship between bone turnover markers and age in female cynomolgus monkeys. Total Body Bone Mineral Density in female cynomolgus monkeys peaked at 10 years of age and then formed a plateau that was maintained until old age. Procollagen I Aminoterminal Propeptide, Bone Alkaline Phosphatase, Osteocalcin, and C-Terminal Telopeptide Of Type I Collagen peaked at 1 to 3 years of age and gradually decreased with age, leveling off by 10 years of age. Estradiol, parathyroid hormone, and 25 hydroxyvitamin D, follicle-stimulating hormone, luteinizing hormone, were not significantly different among age groups. This paper provides data on trends in bone turnover markers throughout the life cycle of female cynomolgus monkeys, which are similar to human changes.