On measures of gametic disequilibrium.
On measures of gametic disequilibrium.
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作者：
R. Lewontin
已经提出了各种方法来表征不同基因座上的等位基因之间的统计关联。赫德里克将这些测量方法与列文丁提出的标准化测量方法D‘进行了比较，理由是后者的测量方法与等位基因频率无关。虽然D‘对所有的等位基因频率都有相同的范围，但实际上，D’并不是与等位基因频率“独立”的，而且对于多位点关联问题来说，没有任何具有这种一般性质的测量是可能的。这个问题之所以无法解决，是因为一般“联想”的定义不明确。
Various measures have been proposed for characterizing the statistical association that arises between alleles at different loci. Hedrick has compared these measures with the standardized measure D' proposed by Lewontin on the grounds that this latter measure is independent of allele frequency. Although D' has the same range for all allelic frequencies, in fact, D' is not "independent" of allele frequency, and no measure with that general property is possible for the multilocus association problem. The insolubility of this problem arises from the ill-defined nature of general "association."