Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice
Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice
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DOI：
10.1038/jcbfm.2011.131
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发表时间：
2012-02-01
影响因子：
6.3
通讯作者：
Whalen, Michael J.
中科院分区：
文献类型：
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作者：
Park, Juyeon;Zhang, Jimmy;Whalen, Michael J.
Akt和哺乳动物雷帕霉素靶蛋白（mTOR）在创伤性脑损伤（TBI）后都被激活，然而两者之间复杂的相互作用阻碍了它们在体内的功能意义。我们研究了Akt/mTOR的单一和组合抑制剂在小鼠控制的皮质撞击（CCI）模型中的作用。CCI后，皮质和海马脑组织匀浆中磷酸化Akt-473（p-Akt）和mTOR下游底物-S6核糖体蛋白（p-S6 RP）增加（P
Akt and mammalian target of rapamycin (mTOR) are both activated after traumatic brain injury (TBI), however complex interplay between the two hampers deciphering their functional implications in vivo. We examined the effects of single and combination inhibitors of Akt/mTOR in a mouse controlled cortical impact (CCI) model. Following CCI, phospho-Akt-473 (p-Akt) and -S6 ribosomal protein (p-S6RP), a downstream substrate of mTOR, were increased in cortical and hippocampal brain homogenates (P