Stromal Cell-derived Factor-1 and Vascular Endothelial Growth Factor May Play an Important Role in the Process of Neovascularization of Herniated Intervertebral Discs
Stromal Cell-derived Factor-1 and Vascular Endothelial Growth Factor May Play an Important Role in the Process of Neovascularization of Herniated Intervertebral Discs
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DOI：
10.1177/147323000903700116
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发表时间：
2009-01-01
影响因子：
1.6
通讯作者：
Qi, F.
中科院分区：
文献类型：
--
作者：
Jia, C-Q;Zhao, J-G;Qi, F.
在某些病理情况下，基质细胞衍生因子 (SDF)-1 水平会升高，但 SDF-1 α 表达与人类椎间盘突出之间的关系尚不清楚。血管内皮生长因子（VEGF）在新血管的形成中起着重要作用。本研究采用免疫组织化学方法测定人椎间盘手术标本中 SDF-1 α 和 VEGF 的表达，以评估它们在新生血管形成中的作用。与膨出、突出和脱垂的椎间盘以及对照椎间盘相比，在突出和隔离的椎间盘中发现 SDF-1 α 和 VEGF 的表达频率显着更高，并且 SDF-1 α 和 VEGF 表达之间存在高度相关性。结论是，SDF-1α和VEGF在人椎间盘中表达，它们的相互作用可能在椎间盘突出的新生血管形成过程中内皮祖细胞的积累中发挥重要作用。
Increased levels of stromal cell-derived factor (SDF)-1 occur in certain pathological situations, however the relationship between SDF-1 alpha expression and human intervertebral disc herniation is unknown. Vascular endothelial growth factor (VEGF) plays an essential role in the formation of new blood vessels. The present study used immunohistochemistry to measure the expression of SDF-1 alpha and VEGF in surgical specimens of human intervertebral discs to evaluate their role in neovascularization. The frequency of expression of SDF-1 alpha and VEGF was found to be significantly higher in extruded and sequestrated herniated intervertebral discs compared with bulging, protruding and prolapsed herniated discs and control discs and there was high correlation between SDF-1 alpha and VEGF expressions. It is concluded that SDF-1 alpha and VEGF are expressed in human intervertebral discs and their interaction may be important in accumulating endothelial progenitor cells during the neovascularization processes in herniated intervertebral discs.