Cerebrospinal fluid levels of tumor necrosis factor alpha and aquaporin 1 in patients with mild cognitive impairment and idiopathic normal pressure hydrocephalus
Cerebrospinal fluid levels of tumor necrosis factor alpha and aquaporin 1 in patients with mild cognitive impairment and idiopathic normal pressure hydrocephalus
复制标题
DOI：
10.1016/j.clineuro.2016.04.025
复制
发表时间：
2016-07-01
影响因子：
1.9
通讯作者：
Castaneyra-Perdomo, Agustin
中科院分区：
文献类型：
--
作者：
Castaneyra-Ruiz, Leandro;Gonzalez-Marrero, Ibrahim;Castaneyra-Perdomo, Agustin
目的：比较分析健康老年人、轻度认知障碍患者和特发性常压脑积水患者脑脊液中肿瘤坏死因子（TNF - α）和水通道蛋白1 （AQP1）的水平。患者和方法：采集7例MCI患者脑脊液样本，平均年龄77岁；6例iNPH，平均年龄75岁；11名平均年龄60岁的健康受试者作为对照。采用酶免疫分析法（ELISA）检测大鼠脑脊液AQP1和TNF α水平。结果：轻度认知障碍患者脑脊液总蛋白含量及脑脊液AQP1和TNF α的相对水平与对照组相似，与iNPH患者不同。另一方面，iNPH患者脑脊液中蛋白质含量低，TNF α或水平显著高，AQP1水平不显著高。结论：这些发现有助于轻度认知障碍患者与正常压力性脑积水患者的鉴别诊断和预后。(C) 2016 Elsevier B.V.版权所有
Objective: The aim of the present work was to make a comparative analysis of the cerebrospinal fluid levels of Tumor necrosis factor (TNF alpha) and aquaporin 1 (AQP1) in (i) healthy elder control, (ii) patients with mild cognitive impairment and, (iii) patients with idiopathic normal pressure hydrocephalus.Patients and methods: Samples of CSF were taken from seven patients with MCI, 77 years average age; six patients with iNPH, 75 years average age; eleven healthy subjects, 60 year average age, were used as controls. The cerebrospinal fluid levels of AQP1 and TNF alpha were studied by enzyme immunoassay (ELISA).Results: In mild cognitive impairment the total protein content of the CSF and the relative CSF levels of AQP1 and TNF alpha were similar to those of control subjects and different from those of iNPH patients. On the other hand, in iNPH patients the CSF content of proteins was low and the levels of TNF alpha or were significantly high while those of AQP1 were insignificantly high.Conclusion: These finding may help the differential diagnosis and prognosis of mild cognitive impairment and normal pressure hydrocephalus patients. (C) 2016 Elsevier B.V. All rights reserved.