Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene.
Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene.
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小鼠 T 细胞受体 α 链基因和 T 细胞 γ 基因的染色体位置。
DOI：
10.1126/science.3918347
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Tonegawa,S
中科院分区：
文献类型：
--
作者：
Kranz,DM;Saito,H;Disteche,CM;Swisshelm,K;Pravtcheva,D;Ruddle,FH;Eisen,HN;Tonegawa,S
用两种独立的方法鉴定了位于两个免疫球蛋白(Ig)样基因家族的小鼠染色体，这两个家族重排并在T淋巴细胞中表达。编码T细胞受体α亚单位的基因位于14号染色体上，其功能尚未确定的伽马基因位于13号染色体上。由于T细胞受体β链的基因先前被证明位于6号染色体上，因此在T细胞中表达和重排的三个免疫球蛋白多基因家族都位于不同的染色体上，就像免疫球蛋白重链的B细胞多基因家族以及免疫球蛋白轻链和免疫球蛋白轻链一样。这些发现不支持早先的观点，即T细胞受体的基因与免疫球蛋白重链基因(小鼠12号染色体)或主要组织相容性复合体(小鼠17号染色体)有关。
Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the α subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor β chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).