CENTRAL ADIPOSITY AND GALLBLADDER-DISEASE IN MEXICAN-AMERICANS
CENTRAL ADIPOSITY AND GALLBLADDER-DISEASE IN MEXICAN-AMERICANS
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DOI：
10.1093/oxfordjournals.aje.a115171
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发表时间：
1989-03-01
影响因子：
5
通讯作者：
HAZUDA, HP
中科院分区：
文献类型：
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作者：
HAFFNER, SM;DIEHL, AK;HAZUDA, HP
肥胖被广泛认为是胆结石的危险因素。然而，据作者所知，只有一项研究调查了身体脂肪分布对胆囊疾病患病率的影响。墨西哥裔美国人是一个以胆囊疾病的高患病率和不利的体脂分布为特征的人群。1979年至1982年圣安东尼奥心脏研究中，作者对1202名墨西哥裔美国人和908名非西班牙裔白人进行了中心性肥胖（以肩胛下皮囊与肱三头肌皮囊的比例测量）是否与临床上明显的胆囊疾病有关。在调整了总体肥胖（以体重指数衡量）和肩胛下皮褶与肱三头肌皮褶的比例后，在墨西哥裔美国妇女中仍观察到胆囊疾病的患病率增加。在女性中，体重指数和肩胛下与肱三头肌皮褶的比例与胆囊疾病呈正相关，而在男性中，体重指数与胆囊疾病相关，而肩胛下与肱三头肌皮褶的比例无关。中心性肥胖也与胆囊疾病妇女心血管危险因素的不良模式有关。
Obesity is widely recognized as a risk factor for gallstones. However, to the authors'' knowledge, only one study was examined the effect of body fat distribution on the prevalence of gallbladder disease. Mexican Americans are a population characterized by both a high prevalence of gallbladder disese and an unfavorable body fat distribution. The authors examined whether central adiposity (as measured by the ratio of subscapular-to-triceps skinfold) was related to clinically evident gallbladder disease in 1,202 Mexican Americans and 908 non-Hispanic whites in the San Antonio Heart Study from 1979 to 1982. After adjustment for overall adiposity (as measured by body mass index) and the ratio of subscapular-to-triceps skinfold, an increased prevalence of gallbladder disease was still observed in Mexican-American women. Both body mass index and the ratio of subscapular-to-triceps skinfold were positively and independently associated with gallbladder disease in women, while in men, body mass index, but not the subscapular-to-triceps skinfold ratio, was associated with gallbladder disease. Central adiposity is also related to the adverse pattern of cardiovascular risk factors observed in women with gallbladder disease.