Improved survival with radiation therapy in high-grade soft tissue sarcomas of the extremities: a SEER analysis.
Improved survival with radiation therapy in high-grade soft tissue sarcomas of the extremities: a SEER analysis.
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高级软组织肉瘤的放射疗法的生存率提高了：SEER分析。
DOI：
10.1016/j.ijrobp.2009.04.051
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发表时间：
2010-05-01
影响因子：
7
通讯作者：
Mohiuddin, Majid M.
中科院分区：
文献类型：
--
作者：
Koshy, Matthew;Rich, Shayna E.;Mohiuddin, Majid M.
肢体软组织肉瘤放射治疗的益处仍有争议。本研究的目的是确定放射治疗对接受保肢手术的肢体原发性软组织肉瘤患者总生存率的影响。一项来自监测、流行病学和最终结果（SEER）数据库的回顾性研究，包括1988年1月1日至2005年12月31日的数据。共有6，960名患者组成了研究人群。使用Kaplan-Meir方法构建低级别和高级别肿瘤患者的总生存曲线。基于多变量考克斯比例风险模型计算风险比。在该队列中，47%接受了放射治疗。放射治疗的低级别肿瘤患者的总生存率无显著差异。在高级别肿瘤中，接受放射治疗的患者的3年总生存率为73%，而未接受放射治疗的患者为63%（p < 0.001）。在多变量分析中，接受放射治疗的高级别肿瘤患者的总生存率提高（HR 0.67，95% CI 0.57-0.79）。在接受放射治疗的患者中，13.5%的患者在新辅助治疗中接受了放射治疗。1988年至2005年，接受新辅助放疗的患者发生率没有显著变化。这是在接受肢体保留手术治疗四肢软组织肉瘤的患者中报告的最大规模的基于人群的研究，并报告了放射治疗与高级别肿瘤患者的生存率改善相关。
The benefit of radiation therapy in extremity soft tissue sarcomas remains controversial. The purpose of this study was determine the effect of radiation therapy on overall survival among patients with primary soft tissue sarcomas of the extremity who underwent limb sparing surgery. A retrospective study from the Surveillance, Epidemiology, and End Results (SEER) database that included data from January 1, 1988, to December 31st, 2005. A total of 6,960 patients comprised the study population. Overall survival curves were constructed using Kaplan-Meir Method and for patients with low and high grade tumors. Hazard ratios were calculated based on multivariable Cox proportional hazards models. Of the cohort, 47% received radiation therapy. There was no significant difference in overall survival among patients with low grade tumors by radiation therapy. In high grade tumors, the 3 year overall survival was 73% in patients who received radiation therapy vs. 63% for those who did not receive radiation therapy (p < 0.001). On multivariate analysis, patients with high grade tumors who received radiation therapy had an improved overall survival (HR 0.67, 95% CI 0.57-0.79). In patients receiving radiation therapy, 13.5% received it in a neo-adjuvant setting. The incidence of patients receiving neo-adjuvant radiation did not change significantly between 1988 and 2005. This is the largest population based study reported in patients undergoing limb sparing surgery for soft tissue sarcomas of the extremities and reports that radiation was associated with improved survival in patients with high grade tumors.
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影响因子：
45.3
作者：
Pisters, PWT;Harrison, LB;Brennan, MF
通讯作者：
Brennan, MF
影响因子：
45.3
作者：
Frustaci, S;Gherlinzoni, F;Picci, P
通讯作者：
Picci, P
影响因子：
8.4
作者：
Storm, HH
通讯作者：
Storm, HH
影响因子：
1.9
作者：
O'Sullivan, Brian;Pisters, Peter W
通讯作者：
Pisters, Peter W
DOI：
10.1016/0360-3016(95)00105-8
发表时间：
1995-07-15
影响因子：
7
作者：
FEIN, DA;LEE, WR;COIA, LR
通讯作者：
COIA, LR