Inhibiting dopamine reuptake blocks the induction of long-term potentiation and depression in the lateral entorhinal cortex of awake rats
Inhibiting dopamine reuptake blocks the induction of long-term potentiation and depression in the lateral entorhinal cortex of awake rats
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DOI：
10.1016/j.neulet.2007.08.025
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发表时间：
2007-10-09
影响因子：
2.5
通讯作者：
Chapman, C. Andrew
中科院分区：
文献类型：
--
作者：
Caruana, Douglas A.;Reed, Sean J.;Chapman, C. Andrew
Synaptic plasticity in olfactory inputs to the lateral entorhinal cortex may result in lasting changes in the processing of olfactory stimuli. Changes in dopaminergic tone can have strong effects on basal evoked synaptic responses in the superficial layers of the entorhinal cortex, and the current study investigated whether dopamine may modulate the induction of long-term potentiation (LTP) and depression (LTD) in piriform cortex inputs to layer 11 of the lateral entorhinal cortex in awake rats. Groups of animals were pretreated with either saline or the selective dopamine reuptake inhibitor GBR 12909 prior to low or high frequency stimulation to induce LTD or Up. In saline-treated groups, synaptic responses were potentiated to 122.4 +/- 6.4% of baseline levels following UP induction, and were reduced to 84.5 +/- 4.9% following induction of LTD. Changes in synaptic responses were maintained for up to 60 min and returned to baseline levels within 24 h. In contrast, induction of both UP and LTD was blocked in rats pretreated with GBR 12909. Dopaminergic suppression of synaptic plasticity in the entorhinal cortex may serve to restrain activity-dependent plasticity during reward-relevant behavioral states or during processing of novel stimuli. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
