Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis
Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis
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DOI：
10.1248/bpb.29.1966
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发表时间：
2006-09-01
影响因子：
2
通讯作者：
Kondo, Ryuichiro
中科院分区：
文献类型：
--
作者：
Arung, Enos Tangke;Shimizu, Kuniyoshi;Kondo, Ryuichiro
为了寻找新的酪氨酸酶抑制物质，我们调查了印尼24科44种药用植物。其中，异叶石竹提取物对酪氨酸酶活性的抑制作用最强。通过活性引导分离，分离出抑制B16黑色素瘤细胞酪氨酸酶活性和黑色素生成的阿托卡帕酮。这种化合物是治疗人类皮肤色素沉着的有力候选药物。
In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin.