INCIDENCE OF END-STAGE RENAL-DISEASE IN TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS IN PIMA-INDIANS
INCIDENCE OF END-STAGE RENAL-DISEASE IN TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS IN PIMA-INDIANS
复制标题
DOI：
10.1007/bf00274774
复制
发表时间：
1988-10-01
期刊：
影响因子：
8.2
通讯作者：
BENNETT, PH
中科院分区：
文献类型：
--
作者：
NELSON, RG;NEWMAN, JM;BENNETT, PH
在亚利桑那州吉拉河印第安社区的皮马印第安人中确定了终末期肾病的发病率，该人群2型（非胰岛素依赖型）糖尿病患病率较高。在1975年至1986年期间，从5059名受试者的研究人群中，80人发生终末期肾病，其中76人（95%）患有2型糖尿病。对终末期肾病病例的审查表明，在糖尿病受试者中，仅2例病例可归因于非糖尿病肾病;所有其他病例均归因于糖尿病肾病。在研究期间，患有糖尿病的皮马印第安人中，终末期肾病的发病率没有变化，男性和女性的发病率相似，并且不受糖尿病诊断时的年龄或达到的年龄的影响，但随着高血压的增加而显著增加（p < 0.05）。归因于糖尿病肾病的终末期肾病的发病率从0-5年的0例/1000人-年增加到≥ 40.8例/1000人-年。糖尿病20年。在这些2型糖尿病受试者中，当比较糖尿病持续时间相似的受试者时，终末期肾病的发生率与在马萨诸塞州波士顿的Joslin诊所随访的1型（胰岛素依赖型）糖尿病受试者相似。
The incidence of end-stage renal disease was determined in the Pima Indians of the Gila River Indian Community in Arizona, a population with a high prevalence of Type 2 (non-insulin-dependent) diabetes mellitus. Between 1975 and 1986, from a study population of 5059 subjects, end-stage renal disease occurred in 80 persons, 76 (95%) of whom had Type 2 diabetes. A review of the cases with end-stage renal disease indicated that among the diabetic subjects only two cases could be attributed to nondiabetic renal diseases; all other cases were attributable to diabetic nephropathy. In diabetic Pima Indians the incidence rate of end-stage renal disease did not change during the study period, was similar in men and women, and was not effected by age at diagosis of diabetes or by attained age, but did increase significantly with hypertension (p < 0.05). The incidence of end-stage renal disease attributed to diabetic nephropathy increased from 0 cases/1000 person-years at 0-5 years to 40.8 cases/1000 person-years at .gtoreq. 20 years duration of diabetes. In these subjects with Type 2 diabetes, the incidence rate of end-stage renal disease was similar to that in subjects with Type 1 (insulin-dependent) diabetes who were followed at the Joslin Clinic in Boston, Massachusetts when those with similar duration of diabetes were compared.