Mal de Debarquement
Mal de Debarquement
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DOI：
10.1001/archotol.125.6.615
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发表时间：
1999-06-01
影响因子：
--
通讯作者：
Rheinberger, MA
中科院分区：
文献类型：
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作者：
Hain, TC;Hanna, PA;Rheinberger, MA
目的：为了更好地定义Mal de Debarquement综合征，了解这种疾病的病因或机制，并寻求更好的预防和治疗方案。设计：患者临床特征调查。背景：通过在俄勒冈州波特兰前庭疾病协会的时事通讯上广告招募参与者。患者：27名Mal de Debarquement综合征患者。结果：几乎所有的被调查者都是中年女性(26/27；平均年龄49.3岁)。症状持续时间为6个月至10年(平均3.5年；SD为2.5年)。23例(85%)患者症状不变。无论是盐酸美克利嗪还是透皮注射东莨菪碱都没有效果。苯二氮卓类药物的益处最大。15名患者接受了平衡康复理疗，他们平均报告的益处很小。结论：MAL的病例数量是以前报道的两倍多。De Debarquement综合征是通过这项研究确定的。这种综合症通常发生在远洋游轮后的中年女性。症状通常对前庭抑制药和物理疗法都难以奏效。
Objectives: To better define mal de debarquement ("sickness of disembarkment") syndrome, to understand the etiology or mechanism of this disorder, and to seek better prevention and treatment options for this disorder.Design: Patient survey of clinical features.Setting: Participants were recruited via advertisement in the newsletter of the Vestibular Disorders Association, Portland, Ore.Patients: Twenty-seven individuals with mal de debarquement syndrome were identified. To be;included in the study, patients must have experienced at least 1 month of rocking or swaying following a cruise or airplane trip of at least 4 hours in duration.Intervention: A questionnaire was administered.Main Outcome Measurer Clinical features of mal de debarquement syndrome.Results: Nearly all respondents were middle-aged women (26 of 27; mean age, 49.3 years). The duration of symptoms ranged from 6 months to 10 years (mean, 3.5 years; SD, 2.5 years). The symptoms were constant in 23 (85%) patients. Neither meclizine hydrochloride nor transdermal scopolamine was helpful. Benzodiazepines were of the most benefit. Balance rehabilitation physical therapy was undertaken by 15 patients, who on average reported a small benefit.Conclusions: More than double the number of previously reported cases of mal. de debarquement syndrome were identified by this study. The syndrome usually occurs in middle-aged women following an ocean cruise. Symptoms are often refractory to vestibular suppressants as well as physical therapy.