[Factors influencing adherence to antibiotic therapy in patients with acute infections].
[Factors influencing adherence to antibiotic therapy in patients with acute infections].
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DOI：
10.6224/jn.62.1.58
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发表时间：
2015-02-01
期刊：
影响因子：
--
通讯作者：
Wang, Tsae-Jyy
中科院分区：
文献类型：
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作者：
Chen, Yi-Chun;Leu, Hsieh-Shong;Wang, Tsae-Jyy
背景技术背景：严格按照医生处方服用抗生素对于保持血液中药物浓度的稳定和达到最佳治疗效果至关重要。近几十年来，抗生素耐药性的增加促使卫生和福利部促进抗生素的合理使用，并使用计算机监测系统来控制医院抗生素的使用。尽管不依从被认为是导致抗菌素耐药性的主要因素，但患者不依从抗生素处方是一个在很大程度上被忽视的问题。本文探讨了这个问题，由于严重的威胁，从抗菌素耐药性和少数研究，调查了病人坚持抗生素治疗的急性感染在Taiwan.Purpose：本研究的目的包括：（1）描述患者对急性感染抗生素治疗的依从性，（2）探索影响抗生素依从性的潜在因素，如人口统计学，疾病特征，方法：本研究采用描述性相关设计。本研究以桃园市传染病门诊为研究对象，采方便抽样法，选取急性感染病例162例。数据收集使用的研究问卷和分析使用卡方检验，Mann-Whitney U检验和logistic regulation.Results：研究结果显示，只有40.1%的患者按照他们的处方服用抗生素完全。其余的人在抗生素效果方面的知识得分低于他们的处方遵守者（U = 2654.5，p = 0.046）。Logistic回归结果显示，知识的影响抗生素是最重要的预测（B = .481，p = .046）的坚持抗生素therapy.CONCLUSIONS：不遵守处方是普遍存在的短期抗生素治疗规定的急性感染。这一发现提醒医疗保健提供者为抗生素治疗的接受者提供适当的教育，即使是那些在门诊环境中接受短期急性感染治疗的人。应特别注意提高患者对抗生素治疗效果的认识和评价。
BACKGROUND: Taking antibiotics in strict adherence to physician prescriptions is crucial for maintaining the stability of the drug concentration in the blood and for achieving the best therapeutic effects. The increasing antimicrobial resistance in recent decades has led the Ministry of Health and Welfare to promote the rational use of antibiotics and the use of a computer monitoring system to control the use of antibiotics in hospitals. Although non-adherence is considered as the major factor contributing to antimicrobial resistance, patient non-adherence to antibiotic prescriptions is an issue that has been largely overlooked. This paper explores this issue due to the serious threat from antimicrobial resistance and the few studies that have investigated patient adherence to antibiotic treatments for acute infections in Taiwan.PURPOSE: The aims of the study include: (1) describe patient's adherence to antibiotic therapy for acute infections and (2) explore the potential factors of influence on antibiotic adherence such as demographics, disease characteristics, and knowledge of antibiotic treatment.METHODS: The study used a descriptive correlational design. A convenience sample of 162 patients with acute infections was recruited from outpatient infectious disease clinics in Taoyuan City. Data were collected using the study questionnaire and analyzed using the chi-square test, Mann-Whitney U test, and logistic regression.RESULTS: The study results showed that only 40.1% of patients followed their prescription to take antibiotics completely. The remainder earned lower scores than their prescription-adhering counterparts for knowledge regarding the effects of antibiotics (U = 2654.5, p = .046). Results of logistic regression showed that knowledge regarding the effects of antibiotics was the most significant predictor (B = .481, p = .046) of adherence to antibiotic therapies.CONCLUSIONS: Non-adherence to prescriptions is prevalent in short-term antibiotic treatments prescribed for acute infections. This finding reminds healthcare providers to provide proper education to the recipients of antibiotic treatments, even those treated for a very short duration for acute infections in outpatient settings. Special attention should be pay to enhancing the understanding and appreciation of patients for the therapeutic effects of antibiotics.