The Prognostic Value of the Expression of SMC4 mRNA in Breast Cancer
The Prognostic Value of the Expression of SMC4 mRNA in Breast Cancer
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DOI：
10.1155/2019/2183057
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发表时间：
2019-11-21
期刊：
影响因子：
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通讯作者：
Wang, Yi-luan
中科院分区：
文献类型：
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作者：
Ma, Rui-min;Yang, Fan;Wang, Yi-luan
的目标。探讨染色体结构维持蛋白4 (SMC4) mRNA在乳腺癌中的表达及临床意义。方法。共对23个配对样本进行了测序，并分析了来自癌症基因组图谱的数据。结果。SMC4 mRNA水平在乳腺癌组织中显著上调（P65），孕酮受体阴性和晚期（III-IV）为独立危险因素（HR=3.293, 95% CI 1.257 ~ 8.625， P=0.015）。在TNBC患者中，SMC4 mRNA的高表达与更好的生存率相关(P
Aim. To investigate the mRNA expression and clinical significance of structural maintenance of chromosomes protein 4 (SMC4) in breast cancer. Methods. A total of 23 paired samples were sequenced, and data from the Cancer Genome Atlas were analyzed. Results. SMC4 mRNA level was significantly upregulated in breast cancer tissues (P65), negative progesterone receptor, and advanced stages (III-IV) were independent risk factors (HR=3.293, 95% CI 1.257-8.625, P=0.015). In patients with TNBC, high mRNA expression of SMC4 correlated with better survival rate (P