Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells
Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells
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DOI：
10.1039/c3cc38693g
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Ahn, Dae-Ro
中科院分区：
文献类型：
--
作者：
Kim, Kyoung-Ran;Kim, Da-Rae;Ahn, Dae-Ro
DNA四面体用于有效递送阿霉素进入耐药性乳腺癌细胞。用DNA纳米构建的药物具有很大的细胞毒性，而游离的阿霉素实际上是耐药细胞的无周期毒性。因此，由固有天然和生物相容性材料制成的DNA四面体可以成为药物载体在癌细胞中克服MDR的良好候选者。
A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.