Association between Aqueous Cytokines and Diabetic Retinopathy Stage.
Association between Aqueous Cytokines and Diabetic Retinopathy Stage.
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DOI：
10.1155/2017/9402198
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发表时间：
2017
影响因子：
1.9
通讯作者：
Tao Y
中科院分区：
文献类型：
--
作者：
Wu H;Hwang DK;Song X;Tao Y
检测不同阶段糖尿病视网膜病变患者房水中细胞因子的浓度。 所有入选的白内障患者分为4组：对照组（无糖尿病患者）、非视网膜病变（NDR）组（无视网膜病变的糖尿病患者）、非增殖性糖尿病视网膜病变（NPDR）组和增殖性糖尿病视网膜病变（PDR）组。采用流式细胞术微球阵列技术检测患者体内白细胞介素1β、IL-2、IL-4、IL-5、IL-6、IL-10、干扰素-γ、肿瘤坏死因子-α和血管内皮生长因子（VEGF）的水溶液浓度。 在本研究中，对照组、NDR组、NPDR组和PDR组分别纳入10例、22例、15例和14例患者。对照组和NDR组之间的所有细胞因子的水性浓度没有观察到差异。相比之下，这些组的比较显示，PDR和NPDR组中大多数炎性细胞因子的水溶液浓度显著更高。此外，PDR组中IL-2、IL-5和VEGF的浓度高于NPDR组。 各种细胞因子的水溶液浓度随着患者的糖尿病视网膜病变的严重程度而增加。这一发现意味着这些细胞因子可能在糖尿病视网膜病变的进展中发挥作用。
To measure the concentrations of various cytokines in the aqueous humor from patients with different stages of diabetic retinopathy. All selected cataract patients were categorized into 4 groups: the control group (patients without diabetes), nonretinopathy (NDR) group (diabetic patients without retinopathy), nonproliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group. The aqueous concentrations of interleukin- (IL-) 1β, IL-2, IL-4, IL-5, IL-6, IL-10, interferon-γ, tumor necrosis factor-α, and vascular endothelial growth factor (VEGF) from patients were measured using the cytometric bead array technique. In this study, 10, 22, 15, and 14 patients were included in the control, NDR, NPDR, and PDR groups, respectively. No difference was observed in the aqueous concentrations of all cytokines between the control group and the NDR group. By contrast, comparison of these groups revealed that the aqueous concentrations of most inflammatory cytokines were significantly higher in the PDR and NPDR groups. In addition, the concentrations of IL-2, IL-5, and VEGF were higher in the PDR group than those in the NPDR group. Aqueous concentrations of various cytokines increased with the severity of patients' diabetic retinopathy. This finding implies that these cytokines might play a role in the progression of diabetic retinopathy.