Circular RNAs in Cardiovascular Disease: An Overview.
Circular RNAs in Cardiovascular Disease: An Overview.
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DOI：
10.1155/2017/5135781
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发表时间：
2017
影响因子：
--
通讯作者：
Xu D
中科院分区：
文献类型：
--
作者：
Fan X;Weng X;Zhao Y;Chen W;Gan T;Xu D
环状RNA（circular RNA，circRNA）是一种新型的内源性非编码RNA（ncRNA），近年来已成为研究热点。CircRNA在生物体中大量稳定存在，具有共价闭合环结构，与线性RNA有很大不同。近年来，越来越多的科学家证实了circRNA在基因表达调控中的重要作用，特别是作为miRNA海绵的作用，并描述了几种circRNA在疾病中的潜在作用机制，暗示了它们的临床治疗价值。本文就circRNA的生物起源、性质及其作为心血管疾病生物标志物的功能和作用作一综述。
Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.