The DECON pilot project investigates predictive markers for successful bariatric surgery.
The DECON pilot project investigates predictive markers for successful bariatric surgery.
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DOI：
10.1038/s41598-023-40452-7
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发表时间：
2023-08-17
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
肥胖是一种慢性、多因素疾病，与许多不良内分泌和代谢状况有关。目前，减肥手术是被诊断患有严重肥胖症的人的最有效的治疗方法之一。然而，目前减肥手术的适应症是基于不充分的指标（即，BMI），这不能解释疾病的复杂性，也不能解释患者人群的异质性。此外，对于影响减肥手术后成功和持续减肥的生物学基础缺乏了解。研究表明，年龄和术前体重是与患者良好结局相关的两个因素。尽管如此，医学上仍然迫切需要确定其他潜在因素，这些因素可以提高候选人选择的特异性，并更好地为肥胖患者的治疗计划提供信息。在本报告中，我们介绍并描述了DECON试点项目的队列，这是一项多中心研究，旨在确定减肥手术后成功减肥的预测生物标志物。
Obesity is a chronic, multifactorial disease which is linked to a number of adverse endocrinological and metabolic conditions. Currently, bariatric surgery is one of the most effective treatments for individuals diagnosed with severe obesity. However, the current indications for bariatric surgery are based on inadequate metrics (i.e., BMI) which do not account for the complexity of the disease, nor the heterogeneity among the patient population. Moreover, there is a lack of understanding with respect to the biological underpinnings that influence successful and sustained weight loss post-bariatric surgery. Studies have implicated age and pre-surgery body weight as two factors that are associated with favorable patient outcomes. Still, there is an urgent medical need to identify other potential factors that could improve the specificity of candidate selection and better inform the treatment plan of patients with obesity. In this report, we present and describe the cohort of the DECON pilot project, a multicenter study which aims to identify predictive biomarkers of successful weight loss after bariatric surgery.
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影响因子：
5.8
作者：
Gu, Zuguang;Eils, Roland;Schlesner, Matthias
通讯作者：
Schlesner, Matthias
DOI：
10.1089/lap.2020.0098
发表时间：
2020-05-14
影响因子：
1.3
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Fournier, Pierre
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作者：
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通讯作者：
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DOI：
10.1001/jama.2018.14433
发表时间：
2018-10-16
期刊：
JAMA
影响因子：
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作者：
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通讯作者：
Courcoulas AP
影响因子：
2.7
作者：
Cadena-Obando, Diego;Ramirez-Renteria, Claudia;Espinosa-Cardenas, Etual
通讯作者：
Espinosa-Cardenas, Etual