INHIBITION OF PHASE-III ACTIVITY BY ACID IN CANINE STOMACH
INHIBITION OF PHASE-III ACTIVITY BY ACID IN CANINE STOMACH
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DOI：
10.1016/0167-0115(94)90022-1
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发表时间：
1994-06-16
影响因子：
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通讯作者：
ITOH, Z
中科院分区：
文献类型：
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作者：
MATSUNAGA, Y;YAMAMOTO, O;ITOH, Z
禁食十二指肠溃疡患者的胃中很少出现消化间期游走性收缩（III 期）的 III 期活动。但其机制尚不清楚。在这项研究中，我们研究了胃和十二指肠酸化对清醒狗上消化道自发 III 期活动的影响。通过长期植入的力传感器监测 5 只有意识的狗的胃和十二指肠运动活动。通过将 pH 玻璃电极放置在胃窦中来测量胃内 pH 值的变化。通过静脉注射实现胃内和十二指肠内酸化。输注组胺，以及通过胃内和十二指肠内滴注不同pH值的酸性溶液。通过放射免疫测定法测量血浆胃动素浓度。组胺（40 μg/kg/h）抑制自发的 III 期活性，但用法莫替丁（一种有效的组胺 H 受体拮抗剂）（0.3 mg/kg，静脉注射）预处理可完全阻止组胺诱导的抑制。 pH 1.0 的胃内酸化强烈抑制自发的 III 相活性，但 pH 2.0 的酸性溶液对抑制 III 相活性没有作用。 pH 1.0 的十二指肠内酸化也抑制自发的 III 相活性。组胺注射以及 pH 1.0 下的胃和十二指肠酸化强烈抑制胃动素的释放。结论是，pH 1.0的胃和十二指肠酸化抑制了自发III期活性的发生，并且pH 1.0的胃和十二指肠酸化抑制内源性胃动素释放参与了这种抑制机制。
Very few phase III activity of the interdigestive migrating contractions (phase III) occurs in the stomach of fasted duodenal ulcer patients. But the mechanism is not well understood. In this study, we studied the effect of gastric and duodenal acidification on the spontaneous phase III activity in the upper gastrointestinal tract of conscious dogs. Gastric and duodenal motor activity in 5 conscious dogs was monitored by means of chronically implanted force transducers. Intragastric pH changes were measured by placing a pH glass electrode in the gastric antrum. Intragastric and intraduodenal acidification was achieved by i.v. infusion of histamine, and by intragastric and intraduodenal instillation of acidic solutions of different pHs. The plasma motilin concentrations were measured by radioimmunoassay. Histamine (40 mu g/kg/h) inhibited spontaneous phase III activity, but the histamine-induced inhibition was completely prevented by pretreatment with famotidine, a potent histamine H, receptor antagonist (0.3 mg/kg, i.v.). Intragastric acidification at pH 1.0 strongly inhibited spontaneous phase III activity, but an acidic solution at pH 2.0 had no effect in inhibiting phase III activity. Intraduodenal acidification at pH 1.0 also inhibited spontaneous phase III activity. Histamine injection and gastric and duodenal acidification at pH 1.0 strongly suppressed motilin release. It is concluded that gastric and duodenal acidification at pH 1.0 inhibits the occurrence of the spontaneous phase III activity, and the suppression of endogenous release of motilin due to gastric and duodenal acidification at pH 1.0 is involved in this inhibitory mechanism.