Serotonergic responsiveness in human cocaine users
Serotonergic responsiveness in human cocaine users
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DOI：
10.1016/j.drugalcdep.2006.06.007
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发表时间：
2007-01-12
影响因子：
4.2
通讯作者：
Baumann, Michael H.
中科院分区：
文献类型：
--
作者：
Ghitza, Udi E.;Rothman, Richard B.;Baumann, Michael H.
背景资料：动物实验表明，重复注射可卡因可诱导脑5-羟色胺（5-羟色胺，或5-HT）功能的变化，这可以通过改变对可卡因能药物激发的神经内分泌反应来检测。研究人类可卡因用户给予了一个cocaine能的挑战产生了不一致的results.Methods：激素反应诱发的5-HT受体D，L-芬氟拉明（FEN）进行了检查，在8个人类可卡因用户居住在一个封闭的研究病房。FEN（60 mg口服）在7天无可卡因期后和5天每日鼻内可卡因（96 mg）和活性安慰剂（4 mg可卡因）双盲给药期后3天给药。血浆皮质醇和催乳素水平测定后，FEN的挑战，可卡因和安慰剂administration.Results后：可卡因显着升高血浆皮质醇水平类似clearee，在第一和第五天的管理，但没有改变催乳素水平的任何一天。第一个FEN挑战显着增加血浆催乳素和皮质醇，而第二次挑战只增加催乳素。结论：鼻内可卡因增加血浆皮质醇不影响催乳素，没有证据表明耐受性。可卡因暴露后FEN诱导的皮质醇分泌减少表明，在早期可卡因戒断期间5-HT传递的缺陷可能有助于维持药物依赖。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Background: Animal experiments show that repeated cocaine injections induce changes in brain serotonin (5-hydroxytryptamine, or 5-HT) function which can be detected by altered neuroendocrine responsiveness to serotonergic drug challenge. Studies of human cocaine users given a serotonergic challenge have produced inconsistent results.Methods: Hormone responses evoked by the 5-HT releaser D,L-fenflurainine (FEN) were examined in eight human cocaine users who resided on a closed research ward. FEN (60 rug oral) was given after a 7-day cocaine-free period and 3 days after a 5-day period of daily double-blind administration of intranasal cocaine (96 mg) and active placebo (4 mg cocaine). Plasma cortisol and prolactin levels were measured after FEN challenges, and after cocaine and placebo administration.Results: Cocaine significantly elevated plasma cortisol levels to a similar clearee, on the first and fifth days of administration, but did not alter prolactin levels on either day. The first FEN challenge significantly increased plasma prolactin and cortisol, whereas the second challenge increased only prolactin.Conclusions: Intranasal cocaine increases plasma cortisol without affecting prolactin, with no evidence for tolerance. The reduction in FEN-induced cortisol secretion after cocaine exposure suggests that deficits in 5-HT transmission during early cocaine abstinence might contribute to the maintenance of drug dependence. (c) 2006 Elsevier Ireland Ltd. All rights reserved.