History of childhood abuse and alcohol use disorder: Relationship with intermittent explosive disorder and intoxicated aggression frequency.
History of childhood abuse and alcohol use disorder: Relationship with intermittent explosive disorder and intoxicated aggression frequency.
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DOI：
10.1016/j.jpsychires.2020.02.025
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发表时间：
2020-02
影响因子：
4.8
通讯作者：
Alexander Puhalla;M. Berman;E. Coccaro;Maria Fahlgren;M. McCloskey
中科院分区：
文献类型：
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作者：
Alexander Puhalla;M. Berman;E. Coccaro;Maria Fahlgren;M. McCloskey
间歇性爆炸障碍(IED)是以情绪性攻击为主要症状的唯一精神诊断，与儿童期虐待史和酒精使用障碍(AUD)的诊断有独特的联系。此外，儿童期虐待和AUD都与普遍的攻击性和醉酒时的攻击性增加有关。然而，到目前为止，还没有研究考察儿童期虐待和AUD对IED的相对贡献，也没有研究它们对有和没有IED的人的总体和醉人攻击行为的影响。以下研究旨在填补这些空白。参与者为493人(68%为女性；年龄为26.65岁)，或有(n=265)有IED者，或无(精神控制组；n=2228)IED者。所有参与者都完成了临床访谈，以(A)诊断AUD、IED和其他共病精神障碍；(B)评估儿童期虐待史；(C)确定一生中总体和醉酒攻击的频率。结果表明，儿童期虐待史，而不是AUD状态，是唯一预测IED状态的因素。在攻击频率方面，简易爆炸装置、急性精神障碍和儿童期虐待都与总体攻击行为独立相关，尽管只有患有简易精神障碍的人表现出醉人的攻击行为随着急性精神障碍的严重程度而增加。总体而言，这些结果表明，儿童期虐待史可能会增加参与全面攻击和患上IED的机会，这反过来可能会增加AUD严重程度与醉酒攻击之间的关联。
Intermittent Explosive Disorder (IED), the only psychiatric diagnosis for which affective aggression is the cardinal symptom, is uniquely associated with both a history of childhood abuse and a diagnosis of an alcohol use disorder (AUD). Moreover, both childhood abuse and AUD are associated with increased general aggression and aggression while intoxicated. Yet, no study to date has examined the relative contributions of childhood abuse and AUD to IED, nor their effects on overall and intoxicated aggression among those with and without IED. The following study aimed to fill these gaps. Participants were 493 individuals (68% female; AgeM= 26.65) either with (n= 265) or without (psychiatric control group;n= 228) IED. All participants completed a clinical interview to (a) diagnose AUD, IED, and other comorbid psychiatric disorders; (b) assess childhood abuse history; and (c) determine lifetime frequency of overall and intoxicated aggression. Results indicated that a history of childhood abuse, but not AUD status, was uniquely predictive of IED status. With regard to aggression frequency, IED, AUD and childhood abuse were all independently associated with overall aggression, although only those with IED showed increased intoxicated aggression as a function of AUD severity. Overall, these results suggest that a history of childhood abuse may increase the chances of engaging in overall aggression and developing IED, which in turn may increase the association between AUD severity and intoxicated aggression.