Inflammatory bowel disease Part 1: ulcerative colitis--pathophysiology and conventional and alternative treatment options.
Inflammatory bowel disease Part 1: ulcerative colitis--pathophysiology and conventional and alternative treatment options.
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发表时间：
2003-08
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通讯作者：
K. Head;Julie S. Jurenka
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作者：
K. Head;Julie S. Jurenka
溃疡性结肠炎(UC)是炎症性肠病的一个亚类，在美国有100-200万人受到影响，在世界各地也有更多人受到影响。虽然溃疡性结肠炎的确切原因仍不确定，但这种情况似乎与遗传和环境因素有关。虽然常规治疗可以有效地维持缓解和缩短活动期，但这些治疗并不是没有副作用，而且相当数量的UC患者即使是最强的药物也没有反应。本文综述了潜在的非常规治疗方法--透皮尼古丁、肝素、褪黑素、脱氢表雄酮、益生菌、纤维、饮食变化、植物性药物、必需脂肪酸和其他营养素--可与传统方法结合考虑，或作为综合替代治疗方案的一部分。此外，本文还讨论了该病的危险因素、发病机制、营养缺乏、常规治疗方法和肠道外表现。
Ulcerative colitis (UC), a subcategory of inflammatory bowel disease, afflicts 1-2 million people in the United States, and many more worldwide. Although the exact cause of ulcerative colitis remains undetermined, the condition appears to be related to a combination of genetic and environmental factors. While conventional treatments can be effective in maintaining remission and decreasing the length of active disease periods, the treatments are not without side effects, and a significant number of people suffering from UC fail to respond to even the strongest drugs. This article reviews potential unconventional treatments - transdermal nicotine, heparin, melatonin, DHEA, probiotics, fiber, dietary changes, botanicals, essential fatty acids, and other nutrients - that may be considered in conjunction with conventional approaches or as part of a comprehensive alternative treatment protocol. In addition this review addresses risk factors, pathogenesis, nutrient deficiencies, conventional treatment approaches, and extra-intestinal manifestations of the disease.