Maternal Stress and Depressive Symptoms and Infant Development at Six Months: the Mothers and Children's Environmental Health (MOCEH) Prospective Study.
Maternal Stress and Depressive Symptoms and Infant Development at Six Months: the Mothers and Children's Environmental Health (MOCEH) Prospective Study.
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DOI：
10.3346/jkms.2016.31.6.843
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发表时间：
2016-06
影响因子：
4.5
通讯作者：
Kim Y
中科院分区：
文献类型：
--
作者：
Bhang SY;Ha E;Park H;Ha M;Hong YC;Kim BN;Lee SJ;Lee KY;Kim JH;Jeong J;Jeong KS;Lee B;Kim Y
我们的目的是评估产前母亲压力和抑郁症状之间的关系，分别以及6个月时婴儿神经发育，调整重金属和氧化应激。这项研究是韩国一项多中心出生队列研究的一部分。使用社会心理健康指数短表（PWI-SF）和流行病学研究中心抑郁量表（CES-D）收集妊娠早期压力和抑郁症状的信息。采用包括标准化心理发展指数（MDI）和精神运动发展指数（PDI）在内的韩国贝利婴儿发展量表- ii （bsidi - ii）和韩国年龄与阶段问卷（K-ASQ）对6月龄婴儿进行评估。指数得分越高，说明发展越好。641名婴儿中，320名女婴（50%）。经社会经济因素调整后，妊娠早期产妇PWI≥29 （vs. PWI≤18）与MDI评分降低5.37分相关（P = 0.02）。妊娠早期产妇ce - d≥26 （vs. ce - d≤10）与MDI评分降低8.18分相关（P = 0.01）。即使在调整铅、镉和丙二醛水平后，相关性仍然显著（P < 0.05）。然而，未发现产妇PWI/CES-D与PDI评分之间存在关联。应激与铅暴露之间没有相互作用。我们发现产前母亲压力和抑郁症状之间的负相关，以及6个月大婴儿在调整产前铅暴露后的MDI评分，已知铅暴露会对认知功能产生负面影响。
Our objective is to evaluate the relationships between prenatal maternal stress and depressive symptoms, respectively, and infant neurodevelopment at 6 months, adjusted for heavy metals and oxidative stress. This research is a part of a multi-center birth cohort study in South Korea. Information on stress and depressive symptoms was collected during the first trimester using Psychosocial Well-Being Index Short Form (PWI-SF) and Center for Epidemiological Studies Depression Scale (CES-D). The Korean Bayley Scales of Infant Development-II assessment (BSID-II), which includes the standardized mental development index (MDI) and psychomotor developmental index (PDI), and Korean Ages & Stages Questionnaires (K-ASQ) were applied to infants at six months of age. A higher index score indicates better development. Among 641 babies, 320 were female (50%). Maternal PWI ≥ 29 (vs. PWI ≤ 18) during early pregnancy was associated with a decrease in MDI scores of 5.37 points (P = 0.02) after adjusting for socioeconomic factors. Maternal CES-D ≥ 26 (vs. CES-D ≤ 10) during early pregnancy was associated with a decrease in MDI scores of 8.18 points (P = 0.01). The associations remained significant even after adjustment for lead, cadmium, and MDA levels (P < 0.05). However, no association was found between maternal PWI/CES-D and PDI score. No interaction was observed between stress and lead exposure. We found an inverse association between prenatal maternal stress and depressive symptoms, and MDI scores in 6-month-old infants after adjustment for prenatal lead exposure, which is known to affect cognitive function negatively.