Tumor characteristics involved in the metastatic behaviour as an improvement in primary cutaneous melanoma prognostics.
Tumor characteristics involved in the metastatic behaviour as an improvement in primary cutaneous melanoma prognostics.
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肿瘤特征涉及转移行为，可改善原发性皮肤黑色素瘤的预后。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
F. Otto
中科院分区：
文献类型：
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作者：
T. Goldmann;D. Ribbert;L. Suter;M. Brode;F. Otto
我们报告了一项回顾性免疫组化研究的结果，常规固定，石蜡包埋组织从147原发性皮肤黑色素瘤属于类pT3和pT4，其发展已被跟踪至少五年。参数组织蛋白酶B、组织蛋白酶D、胶原酶IV、金属硫蛋白和PCNA选自先前对小集合体的研究。所有参数显示转移性和非转移性组之间的肿瘤的统计学显著差异。组织蛋白酶B、组织蛋白酶D和胶原酶IV在肿瘤浸润前沿的表达尤为明显。基于这些数据，我们提出了一个程序，结合这些数据与已建立的临床组织学参数，如肿瘤厚度和溃疡的综合个人风险因素，提高黑色素瘤预后的确定性。
We report the results of a retrospective immunohistochemical study on routinely fixed, paraffin embedded tissues from 147 primary cutaneous melanomas belonging to the classes pT3 and pT4, the development of which has been followed for at least five years. The parameters Cathepsin B, Cathepsin D, Collagenase IV, Metallothionein and PCNA were selected from previous studies on small collectives. All parameters showed statistically significant differences between tumors of the metastatic and the nonmetastatic group. Particularly conspicuous was the expression of Cathepsin B, Cathepsin D and Collagenase IV at the dermal invading front of the tumors. Based on this data we present a procedure of combining these data with established clinical-histological parameters such as tumor thickness and ulceration to an integrated individual risk factor that improves the certainty of melanoma prognosis.