SECRETORY TRANSPORT IN PLASMODIUM
SECRETORY TRANSPORT IN PLASMODIUM
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DOI：
10.1016/0169-4758(93)90216-3
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发表时间：
1993-03-01
期刊：
影响因子：
--
通讯作者：
HALDAR, K
中科院分区：
文献类型：
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作者：
ELMENDORF, HG;HALDAR, K
人类疟原虫恶性疟原虫的无性血液阶段存在于成熟的红细胞内-一种没有细胞内细胞器和很少生物合成活性的细胞。然而，疟原虫作为一种活跃生长和分裂的细胞，对营养物质的摄取和废物的排出有许多要求。因此，寄生虫必须广泛改造红细胞以促进其生存，不仅通过输出大量蛋白质，而且还通过提供运输蛋白质的必要机制。在这篇评论中，Heidi Elmendorf和Kasturi Haldor提出了恶性疟原虫分泌的模型。
The asexual blood stage of the human malaria parasite Plasmodium falciparum resides within the mature erythrocyte - a cell that has no intracellular organelles and few biosynthetic activities. However, Plasmodium, as an actively growing and dividing cell, has numerous requirements for the uptake of nutrients and expulsion of waste. Hence, the parasite must extensively remodel the erythrocyte to facilitate its survival, not only by exporting numerous proteins, but also by providing the requisite machinery for their trafficking. In this review, Heidi Elmendorf and Kasturi Haldor propose a model for secretion in P. falciparum.