The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum
The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum
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DOI：
10.1016/s0925-4773(02)00067-9
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发表时间：
2002-06-01
影响因子：
2.6
通讯作者：
Lumsden, A
中科院分区：
文献类型：
--
作者：
Gogoi, RN;Schubert, FR;Lumsden, A
我们从小鸡和小鼠中分离出一种配对型同源盒基因Dmbx1，以前称为Atx （Development 128(2001) 4789）。序列相似性表明该痤疮与Otx基因高度相关。Dmbx1在原肠胚形成期间开始表达，在前神经板周围的新月形中检测到转录本。随着发育的进展，Dmbx1标志着未来的中脑和前直肠。Dmbx1与Otx2具有相同的尾侧表达边界，而表达在尾部被联脑-头侧边界明显分隔，后来局限于后联脑。在后期，Dmbx1在后脑和脊髓的动态区域表达。其他表达部位包括气孔外胚层和前肠内胚层、体前中胚层和鼻窝。(C) 2002爱思唯尔科学爱尔兰有限公司版权所有。
We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this acne is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.