A red emission fluorescent probe for hydrogen sulfide and its application in living cells imaging
A red emission fluorescent probe for hydrogen sulfide and its application in living cells imaging
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硫化氢红光荧光探针及其在活细胞成像中的应用
DOI：
10.1016/j.tetlet.2013.03.133
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发表时间：
2013-06-05
影响因子：
1.8
通讯作者：
Cui, Jingnan
中科院分区：
文献类型：
--
作者：
Chen, Tao;Zheng, Yi;Cui, Jingnan
H2S作为一种重要的生物信使，其荧光探针的设计已引起人们的广泛关注，以满足对H2S的准确检测的要求。基于叠氮化合物与H2S还原成胺的反应，以二氰基亚甲基二氢呋喃为荧光团，利用其长激发波长和长发射波长，开发了一种新的H2S红色荧光探针。该探针对H2S的选择性高于竞争性阴离子和含硫化物的分析物。最后，将该探针用于检测活细胞中的H2S。皇冠版权所有（C）2013由爱思唯尔有限公司出版。保留所有权利。
Hydrogen sulfide has emerged as an important biological messenger and much attention has been paid to the design of fluorescent probes for H2S to meet the requirement of accurate measurement of H2S. In this work, a new red emission fluorescent probe for H2S was developed based on the reduction reaction of azide with H2S to amine with the fluorophore of dicyanomethylenedihydrofuran because of its long excitation and emission wavelength. The probe has a high selectivity for H2S over competitive anions and sulfide-containing analytes. Finally, the probe was applied to sense H2S in living cells. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.